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Article ID: CBB001510253

That 70s Show: Regulation, Evolution and Development beyond Molecular Genetics (2015)

Suárez-Díaz, Edna (Author)
García-Deister, Vivette (Author)

History and Philosophy of the Life Sciences
Volume: 36, no. 4
Issue: 4
Pages: 503-524
Publication date: 2015
Language: English

DOI: 10.1007/s40656-014-0051-9

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Evolution Molecular biology Metabolism; physiological chemistry Experimental method Experimental biology DNA; RNA Genetic engineering 20th century, late Britten, Roy J. Davidson, Eric Zuckerkandl, Emile

This paper argues that the “long 1970s” (1969--1983) is an important though often overlooked period in the development of a rich landscape in the research of metabolism, development, and evolution. The period is marked by: shrinking public funding of basic science, shifting research agendas in molecular biology, the incorporation of new phenomena and experimental tools from previous biological research at the molecular level, and the development of recombinant DNA techniques. Research was reoriented towards eukaryotic cells and development, and in particular towards “giant” RNA processing and transcription. We will here focus on three different models of developmental regulation published in that period: the two models of eukaryotic genetic regulation at the transcriptional level that were developed by Georgii P. Georgiev on the one hand, and by Roy Britten and Eric Davidson on the other; and the model of genetic sufficiency and evolution of regulatory genes proposed by Emile Zuckerkandl. These three cases illustrate the range of exploratory hypotheses that characterised the challenging landscape of gene regulation in the 1970s, a period that in hindsight can be labelled as transitional, between the biology at the laboratory bench of the preceding period, and the biology of genetic engineering and intensive data-driven research that followed.

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