Article ID: CBB988568054

A Future History of Selectivity in Organic Chemistry: Whence, Where, and Whither? (2022)

unapi

A series of historical snippets of milestones in the development of selectivity in organic synthesis is presented, followed by a few prognostications about future directions in selectivity in organic synthesis—contingent on the cautionary observation that major advances are not always recognized as such at the time. The historical snippets include the foundational landmarks: the unambiguous synthesis of acetic acid from only inorganic substances by Kolbe, the Structural Theory by Couper and Kekulé and its modification by Butlerov in 1861, and the tetrahedral carbon of van’t Hoff and Le Bel. Physical chemists and physical organic chemists provided insights into rates and mechanisms of reaction. In the space of a century and a half, organic synthesis had passed through eras of chemoselectivity, regioselectivity, and diastereoselectivity, to enantioselectivity. Along with advances in spectroscopy and separations techniques, the rise of computational chemistry has added yet another tool to the arsenal of organic chemists.

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Authors & Contributors
Rocke, Alan J.
Lewis, David E.
Dayan, Anthony D.
Gaya, Hannah
Goodwin, William
Grossman, Robert B.
Journals
Bulletin for the History of Chemistry
Journal of Chemical Education
Ambix: Journal of the Society for the History of Alchemy and Chemistry
British Journal for the History of Science
British Journal for the Philosophy of Science
Janus: revue internationale de l'histoire des sciences, de la medecine, de la pharmacie et de la technique
Publishers
American Chemical Society
The MIT Press
University of California Press
University of Chicago Press
Concepts
Organic chemistry
Structural chemistry
Stereochemistry
Chemistry
Development of science; change in science
Primary literature (historical sources)
People
Kekulé von Stradonitz, Friedrich August
Hoff, Jacobus Henricus van't
Kolbe, Hermann
Butlerov, Aleksandr Mikhailovich
Le Bel, Joseph Achille
Liebig, Justus von
Time Periods
19th century
20th century
20th century, late
Places
Germany
Japan
Institutions
Universitet Kazan
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