Article ID: CBB981072036

Situated Practice and the Emergence of Ethical Research: HPV Vaccine Development and Organizational Cultures of Translation at the National Cancer Institute (September 2018)

unapi

This article explores the role scientists at the National Cancer Institute (NCI), a US federal science agency, played in researching and testing vaccines against the human papillomavirus (HPV). Drawing upon archival sources and oral history interview data, I challenge narratives that attribute the design of HPV vaccines to profit motive. Instead, I show that the researchers who developed the technology attempted to construct ethical approaches to vaccine development based on the values that emerged from their situated environments of technological, organizational, and institutional constraint. I argue that interpretations of “translational research” native to the NCI influenced these researchers’ efforts to design and test HPV vaccines. The organizational culture of translational research emerging in the NCI positioned intramural research as a countervailing and supplementary force to market-oriented translational research and development. Over time, NCI researchers’ conceptions of the Institute’s role allowed them to develop understandings of ethical HPV vaccine research as oriented toward addressing cervical cancer health disparities, especially in developing nations. NCI scientists’ understanding of their role in serving the public good through continued HPV vaccine innovation reflects the material and political economic environment they faced at different historical junctures that constrained the possibilities for innovation and ethical action.

...More
Citation URI
https://data.isiscb.org/isis/citation/CBB981072036/

Similar Citations

Article Carmen McLeod; Sarah Hartley; (July 2018)
Responsibility and Laboratory Animal Research Governance (/isis/citation/CBB564349730/)

Article Mattia Andreoletti; David Teira; (2019)
Rules versus Standards: What Are the Costs of Epistemic Norms in Drug Regulation? (/isis/citation/CBB881753075/)

Article Akos Kokai; Alastair Iles; Christine Meisner Rosen; (November 2021)
Green Design Tools: Building Values and Politics into Material Choices (/isis/citation/CBB745455255/)

Article Allison Loconto; Scott Prudham; Steven Wolf; (2024)
Environmental governance through metrics: guest introduction (/isis/citation/CBB894684908/)

Article Jenny Andersson; Erik Westholm; (2019)
Closing the Future: Environmental Research and the Management of Conflicting Future Value Orders (/isis/citation/CBB589179620/)

Article Emmanuel Henry; (September 2021)
Governing Occupational Exposure Using Thresholds: A Policy Biased Toward Industry (/isis/citation/CBB676852860/)

Article Kris Hartley; (November 2021)
Public Trust and Political Legitimacy in the Smart City: A Reckoning for Technocracy (/isis/citation/CBB172268665/)

Article Natasha D. Schüll; (March 2022)
Afterword: Shifting the Terms of the Debate (/isis/citation/CBB889022961/)

Article Emmanuel Henry; Valentin Thomas; Sara Angeli Aguiton; Marc-Olivier Déplaude; Nathalie Jas; (September 2021)
Introduction: Beyond the Production of Ignorance: The Pervasiveness of Industry Influence through the Tools of Chemical Regulation (/isis/citation/CBB736985993/)

Article Alexander Rushforth; Thomas Franssen; Sarah de Rijcke; (2019)
Portfolios of Worth: Capitalizing on Basic and Clinical Problems in Biomedical Research Groups (/isis/citation/CBB805796865/)

Article Cook, Brian R.; Kesby, Mike; Fazey, Ioan; Spray, Chris; (October 2013)
The persistence of ‘normal’ catchment management despite the participatory turn: Exploring the power effects of competing frames of reference (/isis/citation/CBB350967664/)

Article Brian Salter; (January 2022)
Markets, Cultures, and the Politics of Value: The Case of Assisted Reproductive Technology (/isis/citation/CBB380652953/)

Article David Moats; Liz McFall; (2019)
In Search of a Problem: Mapping Controversies over NHS (England) Patient Data with Digital Tools (/isis/citation/CBB339833803/)

Book Wailoo, Keith; Livingston, Julie; Epstein, Steven G.; (2010)
Three Shots at Prevention: The HPV Vaccine and the Politics of Medicine's Simple Solutions (/isis/citation/CBB001031343/)

Article Oscar Javier Maldonado Castañeda; (2021)
Connective data: Markov chain models and the datafication of cervical cancer and HPV vaccination in Colombia (/isis/citation/CBB001445188/)

Book Hannaway, Caroline; (2008)
Biomedicine in the Twentieth Century: Practices, Policies, and Politics (/isis/citation/CBB000850366/)

Authors & Contributors
Henry, Emmanuel
Prudham, Scott
Rijcke, Sarah de
Kris Hartley
Greenhough, Beth
Barnett, Allain J.
Concepts
Technoscience; science and technology studies
Power (social sciences)
Governance
Science and politics
Expertise
Environment
Time Periods
21st century
20th century
Places
Hong Kong
Colombia
United States
Sweden
China
Canada
Institutions
National Institute of Mental Health (U.S.)
National Institute of Health (U.S.)
National Cancer Institute (U.S.)
Comments

Be the first to comment!

{{ comment.created_by.username }} on {{ comment.created_on | date:'medium' }}

Log in or register to comment