Article ID: CBB947878756

From Organ Culture to the New 3D Organotypic Culture Systems: Conceptual Pathways (2020)

unapi

Tissue culture, or explantation technique, deeply renewed the experimental method in biology and medicine and the style of observation of life-sustaining processes in multicellular organisms. Lately, the historiography of tissue culture has focused mostly on cell culture, because of its crucial role in the molecularization of biology. The recent revival of 3D organotypic culture, driven by the synergy between tissue microengineering, cell and stem cell biology, fosters a reappraisal of the conceptual, and not only technical, legacy of the older organotypic experimental tradition within the long history of the tissue culture community. Crucial in this respect is the emergence about the 1950s of the notion of microenvironment, which has lately become a cornerstone of the “three-dimensional thinking” paradigm promoted by the new generation of organ culturists committed to a multilevel extension of Systems Biology research.

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Authors & Contributors
Bechtel, William
Callebaut, Werner
Cobb, Matthew
Creager, Angela N. H.
Dröscher, Ariane
Gall, Yasha M.
Journals
History and Philosophy of the Life Sciences
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
American Heritage of Invention and Technology
Annals of the History and Philosophy of Biology
British Journal for the History of Science
Journal of the History of Biology
Publishers
Armando
Crown Publishers
Harvard University Press
Palgrave Macmillan
Fondazione Museo Storico del Trentino
Concepts
Systems biology
Experimental biology
Biology
Organ, tissue, and cell culture
Molecular biology
Genetics
People
Clements, Frederic Edward
Levi, Giuseppe
Levi-Montalcini, Rita
Monod, Jacques
Szilard, Leo
Weiss, Paul A.
Time Periods
20th century
21st century
19th century
17th century
20th century, late
Places
Italy
United States
Great Britain
Soviet Union
Europe
Russia
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