MacLeod, Miles (Author)
Nersessian, Nancy J. (Author)
Modern integrative systems biology defines itself by the complexity of the problems it takes on through computational modeling and simulation. However in integrative systems biology computers do not solve problems alone. Problem solving depends as ever on human cognitive resources. Current philosophical accounts hint at their importance, but it remains to be understood what roles human cognition plays in computational modeling. In this paper we focus on practices through which modelers in systems biology use computational simulation and other tools to handle the cognitive complexity of their modeling problems so as to be able to make significant contributions to understanding, intervening in, and controlling complex biological systems. We thus show how cognition, especially processes of simulative mental modeling, is implicated centrally in processes of model-building. At the same time we suggest how the representational choices of what to model in systems biology are limited or constrained as a result. Such constraints help us both understand and rationalize the restricted form that problem solving takes in the field and why its results do not always measure up to expectations.
...More
Article
Miles MacLeod;
Nancy J. Nersessian;
(2015)
Modeling systems-level dynamics: Understanding without mechanistic explanation in integrative systems biology
(/isis/citation/CBB511081415/)
Article
Janina Wellmann;
(2018)
Gluing Life Together. Computer Simulation in the Life Sciences: An Introduction
(/isis/citation/CBB692492040/)
Article
Moa Carlsson;
(April 2022)
Computing views, remodeling environments
(/isis/citation/CBB726932342/)
Article
Fleischmann, Kenneth R.;
Wallace, William A.;
(Spring 2017)
Ethical Implications of Computational Modeling
(/isis/citation/CBB721562108/)
Book
Sara Green;
(2016)
Philosophy of Systems Biology: Perspectives from Scientists and Philosophers
(/isis/citation/CBB545077792/)
Article
Janina Wellmann;
(2018)
Model and Movement: Studying Cell Movement in Early Morphogenesis, 1900 to the Present
(/isis/citation/CBB034220227/)
Article
Baker, Kevin T.;
(2017)
Simulation and “Seduction” at the Policy Interface
(/isis/citation/CBB450364367/)
Article
McAllister, Therese P.;
van de Lindt, John;
Ellingwood, Bruce;
(Summer 2019)
A Fully Integrated Model of Interdependent Physical Infrastructure and Social Systems
(/isis/citation/CBB495253737/)
Article
Miles MacLeod;
Nancy J. Nersessian;
(2019)
Mesoscopic modeling as a cognitive strategy for handling complex biological systems
(/isis/citation/CBB904044166/)
Article
Carusi, Annamaria;
(2014)
Validation and Variability: Dual Challenges on the Path from Systems Biology to Systems Medicine
(/isis/citation/CBB001421655/)
Book
Giovanni Battimelli;
Giovanni Ciccotti;
Pietro Greco;
(2020)
Computer Meets Theoretical Physics: The New Frontier of Molecular Simulation
(/isis/citation/CBB746858355/)
Article
Julie Jebeile;
(2018)
Explaining with Simulations: Why Visual Representations Matter
(/isis/citation/CBB882900028/)
Article
Armin W. Schulz;
(2015)
The Heuristic Defense of Scientific Models: An Incentive-Based Assessment
(/isis/citation/CBB713628778/)
Article
David Sepkoski;
(2016)
“Replaying Life's Tape”: Simulations, metaphors, and historicity in Stephen Jay Gould's view of life
(/isis/citation/CBB998505163/)
Article
Miles MacLeod;
(2015)
Heuristic Approaches to Models and Modeling in Systems Biology
(/isis/citation/CBB645699525/)
Chapter
Vrishali Subramanian;
Sanjay Chandrasekharan;
Nancy J. Nersessian;
(2012)
Computational Modeling: Is This the End of Thought Experiments in Science?
(/isis/citation/CBB739614030/)
Article
Read, Dwight;
(2013)
Modeling Cultural Idea Systems: The Relationship between Theory Models and Data Models
(/isis/citation/CBB001320395/)
Book
Andrés Luque-Ayala;
Simon Marvin;
(2020)
Urban Operating Systems: Producing the Computational City
(/isis/citation/CBB430857803/)
Article
Christopher M. Kelty;
(2018)
Robot Life: Simulation and Participation in the Study of Evolution and Social Behavior
(/isis/citation/CBB821237689/)
Book
Alban Frei;
(2018)
Sichtbare Netzwerke: Forschungspolitik und Life-Sciences zwischen 1990 und 2016 in der Schweiz. Eine Fallstudie zu SystemsX.ch
(/isis/citation/CBB130161050/)
Be the first to comment!