Article ID: CBB929908273

Diauxic Inhibition: Jacques Monod's Ignored Work (2021)


Diauxie is at the origin of research that led Jacques Monod (1910–1976), François Jacob (1920–2013), and André Lwoff (1902–1994) to win the Nobel Prize in Physiology or Medicine in 1965 for their description of the first genetic regulatory model. Diauxie is a term coined by Jacques Monod in 1941 in his doctoral dissertation that refers to microbial growth in two phases. In this article, we first examine Monod’s thesis to demonstrate how and why Monod interpreted diauxie as a phenomenon of enzyme inhibition or suppression of adaptive enzymes. We also briefly investigate prior enzyme suppression studies, before Monod’s work, which indicate that he is the first person to observe diauxic growth. Second, we analyse Monod’s post-thesis publications throughout his scientific career, revealing that diauxic inhibition was a significant part of Monod’s scientific activities and greatly fascinated Monod until the end of his life. Paradoxically, Monod’s work and interest on diauxic inhibition are still neglected in historical recounts, focused mostly on Monod’s enzymatic adaptation studies. Indeed, we uncovered a statement by Monod’s colleague, Lwoff, who transformed a quotation from Monod by replacing the word phenomenon with enzymatic adaptation, which we believe has influenced historians. Finally, we offer hypotheses to explain why Lwoff altered Monod’s statement.

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Article Pierre Louis Blaiseau; Allyson M. Holmes (2021) Correction to: Diauxic Inhibition: Jacques Monod’s Ignored Work. Journal of the History of Biology (pp. 197-197). unapi

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Authors & Contributors
Méthot, Pierre-Olivier
Loison, Laurent
Ronan Le Roux
Daniel Demellier
Arantza Etxeberria Agiriano
Beneduce, Chiara
Revue d'Histoire des Sciences
Substantia: An International Journal of the History of Chemistry
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Journal of Medical Biography
Isis: International Review Devoted to the History of Science and Its Cultural Influences
D. A. P./Distributed Art Publishers
Edizioni ETS
Cornell University
Molecular biology
Jacob, François
Monod, Jacques
Lwoff, André
Mayo, Herbert
Wiener, Norbert
Volta, Alessandro
Time Periods
20th century
21st century
20th century, late
20th century, early
18th century
London (England)
Florence (Italy)
Institut Pasteur, Paris
Collège de France, Paris

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