Article ID: CBB853489228

A Feeling for the Human Subject: Margaret Lasker and the Genetic Puzzle of Pentosuria (2021)

unapi

In 1933 Margaret Lasker, a biochemist who worked at the labs of Montefiore Hospital in New York, developed an accurate method for the differentiation between pentosuria and diabetes. Research into pentosuria, and mostly its genetic aspects, became Lasker’s lifelong passion. Since research was not part of her job description, she conducted the chief part of her study in her home kitchen. Lasker’s extensive and personal correspondence with her patients and their families may be the secret key for her success in maintaining a prolonged research career against all odds. Laker’s last article was published in 1955 in Human Biology, presenting data on 72 cases of pentosuria, which occurs almost exclusively in Ashkenazi Jews. More than half a century later, and long after Lasker was gone, her well kept data and family records allowed the discovery of two mutations in the DCXR gene, by Mary-Claire King and her team.

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Authors & Contributors
Martins, Lilian A.-C. Pereira
Moore, Martin D.
DiMarco, Marina
Quinn, Jim
Tomasi, Aldo
Stawkowski, Magdalena E.
Concepts
Diabetes
Human genetics
Mutation
Medicine
Biochemistry
Genes
Time Periods
20th century
19th century
20th century, early
21st century
20th century, late
Places
Baja California
Edinburgh
Argentina
United States
Japan
Italy
Institutions
Kaiser-Wilhelm-Gesellschaft zur Förderung der Wissenschaften
Interessengemeinschaft Farbenindustrie Aktiengesellschaft
Bancroft Library
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