Article
ID: CBB853489228

A Feeling for the Human Subject: Margaret Lasker and the Genetic Puzzle of Pentosuria (2021)

unapi
Human genetics Women in medicine Mutation Correspondence and corresponding Diabetes Biochemistry 20th century Lasker, Margaret

In 1933 Margaret Lasker, a biochemist who worked at the labs of Montefiore Hospital in New York, developed an accurate method for the differentiation between pentosuria and diabetes. Research into pentosuria, and mostly its genetic aspects, became Lasker’s lifelong passion. Since research was not part of her job description, she conducted the chief part of her study in her home kitchen. Lasker’s extensive and personal correspondence with her patients and their families may be the secret key for her success in maintaining a prolonged research career against all odds. Laker’s last article was published in 1955 in Human Biology, presenting data on 72 cases of pentosuria, which occurs almost exclusively in Ashkenazi Jews. More than half a century later, and long after Lasker was gone, her well kept data and family records allowed the discovery of two mutations in the DCXR gene, by Mary-Claire King and her team.

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Authors & Contributors
Martins, Lilian A.-C. Pereira
Moore, Martin D.
DiMarco, Marina
Quinn, Jim
Tomasi, Aldo
Stawkowski, Magdalena E.
Journals
Journal of the History of Biology
Mefisto: Rivista di medicina, filosofia, storia
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Science-Fiction Studies
Mendel Newsletter
Journal of Medical Biography
Publishers
University of California, Riverside
Queen's University at Kingston (Canada)
Oregon State University
Wallstein Verlag
Viking
Matthiesen
Concepts
Mutation
Human genetics
Biochemistry
Diabetes
Medicine
Genetics
People
Free, Helen M.
Dubrova, Yuri E.
Moscati, Giuseppe
Mitchell, Peter D.
Vries, Hugo Marie de
Williams, Robert J. P.
Time Periods
20th century
20th century, early
20th century, late
19th century
Early modern
Renaissance
Places
United States
Italy
Germany
Argentina
Japan
Soviet Union
Institutions
Kaiser-Wilhelm-Gesellschaft zur Förderung der Wissenschaften
Interessengemeinschaft Farbenindustrie Aktiengesellschaft
Columbia University (New York City)
Bancroft Library
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