The contribution analyzes two important problems in relation to the complexity of biomedical research today. First, it addresses the question of the epistemological significance of negative results and their disclosure. On the other hand, it addresses the question of the epistemological significance of the often unrealizable replicability of results. Arguments are proposed for the position that the presence of contradictory, i. e., both positive and negative, results within a series of experiments should not diminish the reliability of the sciences themselves in the public mind, since the alleged contradictions represent a new opportunity to reapply the scientific method. Der Beitrag analysiert zwei in Bezug auf die heutige Komplexität der biomedizinischen Forschung wichtige Probleme. Zum einen thematisiert er die Frage nach der epistemologischen Bedeutung negativer Ergebnisse und ihrer Bekanntgabe. Zum anderen behandelt er die Frage der epistemologischen Bedeutung der oft nicht umzusetzenden Replizierbarkeit von Ergebnissen. Es werden Argumente für die These vorgeschlagen, dass das Vorliegen von widersprüchlichen, also sowohl positiven als auch negativen, Ergebnissen innerhalb einer Versuchsreihe nicht die Verlässlichkeit der Wissenschaften selbst in der Öffentlichkeit vermindern sollte, da die vermeintlichen Widersprüche eine neue Gelegenheit darstellen, die wissenschaftliche Methode erneut anzuwenden.
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