Article ID: CBB803744469

The Birth of Modern Industrial Microbiology: The Acetone–Butanol Fermentation (2017)

unapi

Prompted by the exigencies of the First World War, the ability of certain bacteria to produce a mixture of organic solvents from carbohydrates was successfully harnessed as a source of acetone for use in the manufacture of cordite. From pilot plant studies conducted in an East London distillery, it was rapidly developed into what is now recognised as the first modern industrial fermentation process. In the post-war period, the process continued to thrive, especially in North America, as another of its products, butanol, became important in the burgeoning automobile industry. This paper describes the background to the development of acetone–butanol fermentation as an industrial process, its growth during the war years and how it contributed to the development of today’s biotechnology industry producing pharmaceuticals, food additives and many other microbial products.

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Authors & Contributors
Reed, Peter
Coleman, Kim
Freemantle, Michael
Huang, H. T.
Lesch, John E.
Lorencová, Ivana
Journals
International Journal for the History of Engineering and Technology
Ambix: Journal of the Society for the History of Alchemy and Chemistry
Acta Historiae Rerum Naturalium necnon Technicarum
American Historical Review
Annals of Science: The History of Science and Technology
Bulletin for the History of Chemistry
Publishers
Royal Society of Chemistry
Cambridge University Press
Bloomsbury Academic
History Press
Kluwer Academic
Palgrave Macmillan
Concepts
Chemistry
Chemical industry
World War I
Science and war; science and the military
Chemical compounds
Biotechnology
People
Calmette, Albert
Duisberg, Carl
Keir, James
Moulton, John Fletcher
Needham, Joseph
Tillmanns, Heinrich
Time Periods
20th century
20th century, early
19th century
18th century
21st century
Ancient
Places
Great Britain
Germany
United States
China
Japan
Czechoslovakia
Institutions
Great Britain. Royal Navy
Imperial Chemical Industries
Interessengemeinschaft Farbenindustrie Aktiengesellschaft
Lunar Society of Birmingham (England)
IG Farben
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