Article ID: CBB799911715

The Concepts of Ludwik Fleck and their Application to the Eukaryotic Cell Cycle (2017)

unapi

The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner. Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.

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Authors & Contributors
Oxana Kosenko
Fiorentino, Alexander R.
Dammann, Olaf
Rydlewski, Michał
Jiang, Lijing
Wiesemann, Claudia
Concepts
Microbiology
Cellular biology
Methodology of science; scientific method
Explanation; hypotheses; theories
Genes
Philosophy of medicine
Time Periods
19th century
20th century
20th century, late
20th century, early
Places
Russia
Germany
France
Great Britain
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