Article ID: CBB799911715

The Concepts of Ludwik Fleck and their Application to the Eukaryotic Cell Cycle (2017)


The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner. Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.

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Authors & Contributors
Schickore, Jutta
Hudson, Robert G.
Charpa, Ulrich
Stanford, P. Kyle
Duchesneau, François
Dröscher, Ariane
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
History and Philosophy of the Life Sciences
Journal of the History of Biology
Perspectives on Science
Aleph: Historical Studies in Science and Judaism
Berichte zur Wissenschaftsgeschichte
University of London, Imperial College of Science, Technology and Medicine (United Kingdom
University of Toronto Press
Cellular biology
Methodology of science; scientific method
Explanation; hypotheses; theories
Philosophy of medicine
Schleiden, Matthias Jakob
Weismann, August
Golgi, Camillo
Kölliker, Rudolf Albert von
Spallanzani, Lazzaro
Virchow, Rudolf Carl
Time Periods
19th century
20th century
20th century, early
20th century, late
Great Britain

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