Article ID: CBB791455066

“In Praise of Wool”: The Development of Partition Chromatography and Its Under-Appreciated Impact on Molecular Biology (2019)

unapi

The invention of partition chromatography by the biochemists Archer Martin and Richard Synge in 1941 offered crucial insights into the structure and function of DNA, insights at least as important as those from X-ray crystallography. Even so, the role that partition chromatography played in molecular biological studies is far less well known. Using new archival material, this article describes the origins of Martin and Synge’s work, arguing that their achievement was far more than a new technical innovation; it went on to have a profound impact on the development of molecular biology to an extent that scholars have insufficiently appreciated.

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Authors & Contributors
Dahm, Ralf
Rheinberger, Hans-Jörg
Walsby, A. E.
Veigl, Sophie Juliane
Gerontas, Apostolos
Travis, Anthony S.
Concepts
Molecular biology
DNA; RNA
Laboratory techniques and procedures
Chromatography
Scientific apparatus and instruments
Genetics
Time Periods
20th century, late
20th century
20th century, early
19th century
17th century
Places
Germany
England
Spain
Brazil
Institutions
Tübingen. Universität
U.S. Atomic Energy Commission
Atomic Bomb Casualty Commission
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