Article ID: CBB700623394

Celebrando la cristalografía macromolecular: una perspectiva personal (2015)

unapi

ABSTRACT The twentieth century has seen an enormous advance in the knowledge of the atomic structures that surround us. The discovery of the first crystal structures of simple inorganic salts by the Braggs in 1914, using the diffraction of X-rays by crystals, provided the critical elements to unveil the atomic structure of matter. Subsequent developments in the field leading to macromolecular crystallography are presented with a personal perspective, related to the cultural milieu of Spain in the late 1950’s. The journey of discovery of the author, as he developed professionally, is interwoven with the expansion of macromolecular crystallography from the first proteins (myoglobin, hemoglobin) to the ‘coming of age’ of the field in 1971 and the discoveries that followed, culminating in the determination of the structure of the ribosomes at the turn of the century. A perspective is presented exploring the future of the field and also a reflection about the future generations of Spanish scientists. RESUMEN El siglo XX ha sido testigo del increíble avance que ha experimentado el conocimiento de la estructura atómica de la materia que nos rodea. El descubrimiento de las primeras estructuras atómicas de sales inorgánicas por los Bragg en 1914, empleando difracción de rayos X con cristales, proporcionó los elementos clave para alcanzar tal conocimiento. Posteriores desarrollos en este campo, que condujeron a la cristalografía macromolecular, se presentan aquí desde una perspectiva personal, relacionada con el contexto cultural de la España de la década de los 50. La experiencia del descubrimiento científico, durante mi desarrollo profesional, se integra en el desarrollo de la cristalografía macromolecular, desde las primeras proteínas (míoglobina y hemoglobina), hasta su madurez en 1971 que, con los posteriores descubrimientos, culmina con la determinación del la estructura del ribosoma. Asimismo, se explora el futuro de esta disciplina y se reflexiona sobre el futuro de las próximas generaciones de científicos españoles.

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Authors & Contributors
Jenkin, John G.
Anduaga Egaña, Aitor
Black, Suzanne
Scheffler, Robin Wolfe
López-Ocón Cabrera, Leonico
Aragón Albillos, Santiago
Journals
Arbor: Ciencia, Pensamiento y Cultura
Asclepio: Archivo Iberoamericano de Historia de la Medicina
Minerva: A Review of Science, Learning and Policy
Archives Internationales d'Histoire des Sciences
Configurations: A Journal of Literature, Science, and Technology
Studies in History and Philosophy of Science
Publishers
CEIMES
Oxford University Press
Concepts
Education
X-ray crystallography
Crystallography
Physics
Chemistry
Biology
People
Bragg, William Lawrence
Bragg, William Henry
Vand, Vladimir
Laue, Max von
Knipping, Paul
Bell, Florence
Time Periods
20th century, early
19th century
18th century
20th century, late
20th century
Places
Spain
Great Britain
Madrid (Spain)
Czechoslovakia
Portugal
Institutions
University of Manchester
Cambridge University
Programa EDALNU (EDALNLU program)
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