The physiologist Claude Bernard was an important nineteenth-century methodologist of the life sciences. Here I place his thought in the context of the history of the vera causa standard, arguably the dominant epistemology of science in the eighteenth and early nineteenth centuries. Its proponents held that in order for a cause to be legitimately invoked in a scientific explanation, the cause must be shown by direct evidence to exist and to be competent to produce the effects ascribed to it. Historians of scientific method have argued that in the course of the nineteenth century the vera causa standard was superseded by a more powerful consequentialist epistemology, which also admitted indirect evidence for the existence and competence of causes. The prime example of this is the luminiferous ether, which was widely accepted, in the absence of direct evidence, because it entailed verified observational consequences and, in particular, successful novel predictions. According to the received view, the vera causa standard's demand for direct evidence of existence and competence came to be seen as an impracticable and needless restriction on the scope of legitimate inquiry into the fine structure of nature. The Mill-Whewell debate has been taken to exemplify this shift in scientific epistemology, with Whewell's consequentialism prevailing over Mill's defense of the older standard. However, Bernard's reflections on biological practice challenge the received view. His methodology marked a significant extension of the vera causa standard that made it both powerful and practicable. In particular, Bernard emphasized the importance of detection procedures in establishing the existence of unobservable entities. Moreover, his sophisticated notion of controlled experimentation permitted inferences about competence even in complex biological systems. In the life sciences, the vera causa standard began to flourish precisely around the time of its alleged abandonment.
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