Book ID: CBB668155327

First in Fly: Drosophila Research and Biological Discovery (2018)

unapi

Mohr, Stephanie Elizabeth (Author)


Harvard University Press


Publication Date: 2018
Physical Details: 272
Language: English

A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny?Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases.Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.

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Reviewed By

Review Alice Laciny (2020) Review of "First in Fly: Drosophila Research and Biological Discovery". History and Philosophy of the Life Sciences (p. 14). unapi

Citation URI
https://data.isiscb.org/isis/citation/CBB668155327/

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Authors & Contributors
Dietrich, Michael R.
Brad Bolman
Kitcher, Philip
Holmes, Tarquin
Davies, Gail
Hardesty, Rebecca A.
Concepts
Experimental organisms
Genetics
Laboratory techniques and procedures
Evolution
Biology
Drosophila
Time Periods
20th century
21st century
20th century, early
19th century
Places
United States
Europe
United Kingdom
Germany
Brazil
Institutions
University of California, Berkeley
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