Article ID: CBB645699525

Heuristic Approaches to Models and Modeling in Systems Biology (2015)

unapi

Prediction and control sufficient for reliable medical and other interventions are prominent aims of modeling in systems biology. The short-term attainment of these goals has played a strong role in projecting the importance and value of the field. In this paper I identify the standard models must meet to achieve these objectives as predictive robustness—predictive reliability over large domains. Drawing on the results of an ethnographic investigation and various studies in the systems biology literature, I explore four current obstacles to achieving predictive robustness; data constraints, parameter uncertainty, collaborative constraints and system-scale requirements. I use a case study and the commentary of systems biologists themselves to show that current practices in the field, rather than pursuing these goals, frequently use models heuristically to investigate and build understanding of biological systems that do not meet standards of predictive robustness but are nonetheless effective uses of computation. A more heuristic conception of modeling allows us to interpret current practices as ways that manage these obstacles more effectively, particularly collaborative constraints, such that modelers can in the long-run at least work towards prediction and control.

...More
Citation URI
http://data.isiscb.org/isis/citation/CBB645699525/

Similar Citations

Article Michael Fry; (2018)
Predictive Hypotheses Are Ineffectual in Resolving Complex Biochemical Systems (/isis/citation/CBB002665433/) unapi

Article Janina Wellmann; (2018)
Model and Movement: Studying Cell Movement in Early Morphogenesis, 1900 to the Present (/isis/citation/CBB034220227/) unapi

Article Miles MacLeod; Nancy J. Nersessian; (2018)
Modeling Complexity: Cognitive Constraints and Computational Model-Building in Integrative Systems Biology (/isis/citation/CBB935002178/) unapi

Book Sara Green; (2016)
Philosophy of Systems Biology: Perspectives from Scientists and Philosophers (/isis/citation/CBB545077792/) unapi

Article Miles MacLeod; Nancy J. Nersessian; (2015)
Modeling systems-level dynamics: Understanding without mechanistic explanation in integrative systems biology (/isis/citation/CBB511081415/) unapi

Book Petraitis, Peter Steven; (2013)
Multiple Stable States in Natural Ecosystems (/isis/citation/CBB001421446/) unapi

Article Gonzalo L. Recio; (2021)
On the Use of Tables as Heuristic Tools in Ptolemaic Astronomy (/isis/citation/CBB614559477/) unapi

Article Mahony, Martin; (2014)
The Predictive State: Science, Territory and the Future of the Indian Climate (/isis/citation/CBB001421169/) unapi

Article Greene, Mott T.; (2006)
Looking for a General for Some Modern Major Models (/isis/citation/CBB000771690/) unapi

Article Parker, Wendy S.; (2014)
Simulation and Understanding in the Study of Weather and Climate (/isis/citation/CBB001421044/) unapi

Article Remington J. Moll; Daniel Steel; Robert A. Montgomery; (2016)
AIC and the challenge of complexity: A case study from ecology (/isis/citation/CBB078857465/) unapi

Article Nikos Giatrakos; Nikos Katzouris; Antonios Deligiannakis; Alexander Artikis; Minos Garofalakis; George Paliouras; Holger Arndt; Raffaele Grasso; Ralf Klinkenberg; Miguel Ponce De Leon; Gian Gaetano Tartaglia; Alfonso Valencia; Dimitrios Zissis; (June 2019)
Interactive Extreme-Scale Analytics: Towards Battling Cancer (/isis/citation/CBB319384817/) unapi

Book Ben Martynoga; (2018)
Molecular Tinkering: The Edinburgh Scientists Who Changed the Face of Modern Biology (/isis/citation/CBB777108676/) unapi

Chapter Callebaut, Werner; Müller, Gerd B.; Newman, Stuart A.; (2007)
The Organismic Systems Approach: Evo-Devo and the Streamlining of the Naturalistic Agenda (/isis/citation/CBB001213667/) unapi

Article Jürgen Bereiter-Hahn; (2009)
Is the Term “Individual” Universal for Organisms? (/isis/citation/CBB291130447/) unapi

Chapter Roberto Serra; (2015)
Proprietà generiche nei sistemi complessi (/isis/citation/CBB320748884/) unapi

Article Creager, Angela N. H.; (2013)
Timescapes of Radioactive Tracers in Biochemistry and Ecology (/isis/citation/CBB001211940/) unapi

Article O'Malley, Maureen A.; Soyer, Orkun S.; (2012)
The Roles of Integration in Molecular Systems Biology (/isis/citation/CBB001221587/) unapi

Chapter Bhushan Patwardhan; Gururaj Mutalik; Girish Tillu; (2015)
Systems Biology and Holistic Concepts (/isis/citation/CBB784638262/) unapi

Authors & Contributors
MacLeod, Miles
Nersessian, Nancy J.
Greene, Mott T.
Creager, Angela N. H.
Müller, Gerd B.
Callebaut, Werner
Journals
History and Philosophy of the Life Sciences
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Endeavour: Review of the Progress of Science
Perspectives on Science
Social Studies of Science
Annals of the History and Philosophy of Biology
Publishers
Oxford University Press
Chronos Verlag
Armando
Springer
Troubador Publishing
Concepts
Systems biology
Models and modeling in science
Forecasting; prediction
Data analysis
Philosophy of science
Ecology
People
Ptolemy
Time Periods
21st century
20th century
20th century, late
Ancient
Places
Himalayan Mountains (Nepal)
India
Switzerland
Edinburgh
Institutions
Human Genome Project
Comments

Be the first to comment!

{{ comment.created_by.username }} on {{ comment.created_on | date:'medium' }}

Log in or register to comment