Since ancient times, drugs have been an essential part of the therapeutic and preventive armamentarium. Drugs can be natural products, synthetic chemicals, or biologicals. Advances in chemistry and biology have opened ways for powerful and specific drugs. However, today, new drug discovery is facing major challenges. Many drugs are failing due to toxicity and safety reasons. Currently, drug discovery is facing an innovation deficit. Ayurveda and Traditional and Complementary Medicine(T&CM) have described thousands of drugs and formulations. The authors explain the value of traditional knowledge, like Ayurveda, as a valuable resource for new drug discovery. A few case studies on drugs and adjuvants for metabolic and chronic diseases are presented to illustrate the potential of Ayurveda-inspired drug discovery. The issues related to quality control, standardization, and safety of botanical drugs, as well as the controversy surrounding mercury, and metal-based drugs will be discussed, with help of available scientific research. The authors suggest that the current one target–one drug discovery process needs to move toward formulation discovery, so that multiple targets are systematically addressed. The safe and rational combination of botanical drugs, psycho–neuro–immune–endocrinal and restorative regimens could be the key to future integrative medicine.
...MoreBook Bhushan Patwardhan; Gururaj Mutalik MD; Girish Tillu (2015) Integrative Approaches for Health: Biomedical Research, Ayurveda and Yoga.
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