Article ID: CBB487976291

Much ado about mice: Standard-setting in model organism research (2018)

unapi

Recently there has been a practice turn in the philosophy of science that has called for analyses to be grounded in the actual doings of everyday science. This paper is in furtherance of this call and it does so by employing participant-observation ethnographic methods as a tool for discovering epistemological features of scientific practice in a neuroscience lab. The case I present focuses on a group of neurobiologists researching the genetic underpinnings of cognition in Down syndrome (DS) and how they have developed a new mouse model which they argue should be regarded as the “gold standard” for all DS mouse research. Through use of ethnographic methods, interviews, and analyses of publications, I uncover how the lab constructed their new mouse model. Additionally, I describe how model organisms can serve as abstract standards for scientific work that impact the epistemic value of scientific claims, regulate practice, and constrain future work.

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Authors & Contributors
Brad Bolman
Ankeny, Rachel A.
Creager, Angela N. H.
Crowe, Nathan
Dietrich, Michael R.
Fagan, Melinda Bonnie
Journals
Journal of the History of Biology
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Studies in History and Philosophy of Science
British Journal for the History of Science
History and Philosophy of the Life Sciences
Isis: International Review Devoted to the History of Science and Its Cultural Influences
Publishers
Harvard University Press
Mimesis
Palgrave Macmillan
Concepts
Experimental organisms
Laboratory techniques and procedures
Models and modeling in science
Laboratory animals
Standards and standardization
Biology
People
Little, Clarence Cook
Rader, Karen A.
Bustad, Leo K.
Time Periods
21st century
20th century
20th century, late
19th century
Places
United States
Europe
Chile
Sweden
Washington (state, U.S.)
United Kingdom
Institutions
Hanford Nuclear Site (Washington)
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