Article ID: CBB475661753

Problems and promises: How to tell the story of a Genome Wide Association Study? (2021)

unapi

The promise of treatments for common complex diseases (CCDs) is understood as an important force driving large scale genetics research over the last few decades. This paper considers the phenomenon of the Genome Wide Association Study (GWAS) via one high profile example, the Wellcome Trust Case Control Consortium (WTCCC). The WTCCC despite not fulfilling promises of new health interventions is still understood as an important step towards tackling CCDs clinically. The ‘sociology of expectations’ has considered many examples of failure to fulfil promises and the subsequent negative consequences including disillusionment, disappointment and disinvestment. In order to explore why some domains remain resilient in the face of apparent failure, I employ the concept of the ‘problematic’ found in the work of Giles Deleuze. This alternative theoretical framework challenges the idea that the failure to reach promised goals results in largely negative outcomes for a given field. I will argue that collective scientific action is motivated not only by hopes for the future but also by the drive to create solutions to the actual setbacks and successes which scientists encounter in their day-to-day work. I draw on eighteen interviews.

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Authors & Contributors
García-Sancho, Miguel
Gil Viry
Mark Wong
Rhodri Ivor Leng
James Lowe
Vermeulen, Niki
Concepts
Genomics
Human genetics
Medicine
Genetics
DNA; RNA
Race
Time Periods
21st century
20th century, late
20th century
Places
United States
China
India
Institutions
Human Genome Project
National Human Genome Research Institute
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