Cohen, Jack S. (Author)
Substantia: An International Journal of the History of Chemistry
Volume: 5
Issue: 1
Pages: 9-25
In the search for novel therapeutics, antisense oligonucleotide (ASO) analogs have been a major focus of research for over 40 years. They use the antisense strategy, namely they have a nucleic acid base sequence that is complementary to a portion of a specific mRNA that is produced in the cell, or to a viral RNA, in order to selectively inhibit gene expression. Oligonucleotides need to be chemically modified to stabilize them against hydrolysis by endogenous nucleases. Until now several phosphorothioate (PS) oligonucleotide analogs have been approved by the FDA for human use. This article seeks to provide a history of this subject to date.
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Substantia: An International Journal of the History of Chemistry
Medicina Historica
Mefisto: Rivista di medicina, filosofia, storia
The Chemical Educator
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
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