Article ID: CBB430843736

The Bricolage of Pig Genomics (2022)

unapi

The history of genomic research on the pig (Sus scrofa)—as uncovered through archival research, oral histories, and the analysis of a quantitative dataset and co-authorship network—demonstrates the importance of two distinct genealogies. These consist of research programs focused on agriculturally oriented genetics, on the one hand, and systematics research concerned with evolution and diversity, on the other. The relative weight of these two modes of research shifted following the production of a reference genome for the species from 2006 to 2011. Before this inflection point, the research captured in our networks mainly involved intensive sequencing that concentrated primarily on increasing the resolution of genomic data both in particular regions and more widely across the genome. Sequencing practices later became more extensive, with greater focus on the generation and comparison of sequence data across and between populations. We explain these shifts in research modes as a function of the availability, circulation, distribution, and exchange of genomic tools and resources—including data and materials—concerning the pig in general, and increasingly for particular populations. Consequently, we describe the history of pig genomics as constituting a kind of bricolage, in which geneticists cobbled together resources to which they had access—often ones produced by them for other purposes—in pursuit of their research aims. The concept of bricolage adds to the thicker vision of genomics that we have shown throughout the special issue and further highlights the singularity of the dominant, thin narrative focused on the production of the human reference sequence at large-scale genome centers. This essay is part of a special issue entitled The Sequences and the Sequencers: A New Approach to Investigating the Emergence of Yeast, Human, and Pig Genomics, edited by Miguel García-Sancho and James Lowe.

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Associated with

Article Miguel García-Sancho; James Lowe; Gil Viry; Rhodri Leng; Mark Wong; Niki Vermeulen (2022) Yeast Sequencing: “Network” Genomics and Institutional Bridges. Historical Studies in the Natural Sciences (pp. 361-400). unapi

Article Miguel García-Sancho; Rhodri Leng; Gil Viry; Mark Wong; Niki Vermeulen; James Lowe (2022) The Human Genome Project as a Singular Episode in the History of Genomics. Historical Studies in the Natural Sciences (pp. 320-360). unapi

Article James Lowe; Miguel García-Sancho; Rhodri Leng; Mark Wong; Niki Vermeulen; Gil Viry (2022) Across and within Networks: Thickening the History of Genomics. Historical Studies in the Natural Sciences (pp. 443-475). unapi

Article Rhodri Leng; Gil Viry; Miguel García-Sancho; James Lowe; Mark Wong; Niki Vermeulen (2022) The Sequences and the Sequencers: What Can a Mixed-Methods Approach Reveal about the History of Genomics?. Historical Studies in the Natural Sciences (pp. 277-319). unapi

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Authors & Contributors
James Lowe
García-Sancho, Miguel
Gil Viry
Mark Wong
Rhodri Ivor Leng
Vermeulen, Niki
Concepts
Genomics
Genetics
Molecular sequencing
Human genetics
DNA; RNA
Social networks
Time Periods
21st century
20th century
20th century, late
19th century
Places
United States
China
Belgium
Australia
Wisconsin (U.S.)
Mexico
Institutions
Human Genome Project
Wellcome Trust
National Institutes of Health
Cambridge. University. Laboratory of Molecular Biology
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