Apell, Hans-Jürgen (Author)
Substantia: An International Journal of the History of Chemistry
Volume: 2
Issue: 1
Pages: 17-28
The oppositely oriented concentration gradients of Na+ and K+ ions across the cell membrane as found in animal cells led to the requirement of an active ion-transport mechanism that maintains this steady-state condition. As solution of this problem the Na,K-ATPase was identified, a member of the P-type ATPase family. Its stoichiometry has been defined as 3 Na+/2 K+/1 ATP, and a class of Na,K-ATPase-specific inhibitors, cardiac steroids, was established, which allow the identification of this ion pump. In an effort lasting for several decades structural details were uncovered down to almost atomic resolution. The quaternary structure of the functional unit, either αβ heterodimer or (αβ)n complexes with n ≥ 2, is still under discussion.
...MoreSimilar Citations
Article
Brockwell, John;
Sprent, Janet I.;
Day, David A.;
(2013)
Fraser John Bergersen 1929--2011
Book
Galperin, Charles;
Gilbert, Scott F.;
Hoppe, Brigitte;
(1999)
Fundamental Changes in Cellular Biology in the 20th Century: Biology of Development, Chemistry and Physics in the Life Sciences
Article
Alessandra Passariello;
(2021)
Acidi nucleici, sì, ma quali? Jean Brachet e la spiegazione del differenziamento cellulare
Article
Harman, Oren Solomon;
(2006)
Method as a Function of “Disciplinary Landscape”: C.D. Darlington and Cytology, Genetics and Evolution, 1932--1950
Article
Hodge, Jonathan;
(2010)
The Darwin of Pangenesis
Article
Santesmases, María Jesús;
(2000)
From Intestine Transport to Enzymatic Regulation: The Works of the Spanish Biochemist Alberto Sols (1917--1989)
Book
Adriana Giannini;
(2021)
Lynn Margulis: la scoperta dell'evoluzione come cooperazione
Chapter
Aldo Fasolo;
Davide Lovisolo;
(2015)
"The Cell in Development and Inheritance", centoventi anni dopo. E.B. Wilson, la teoria cellulare e il tassello mancante: la membrana plasmatica
Book
Alessandro Minelli;
(2015)
Descrivere e interpretare il vivente
Book
Paul G. Falkowski;
(2015)
Life's Engines: How Microbes Made Earth Habitable
Article
Müller-Wille, Staffan;
(2007)
Hybrids, Pure Cultures, and Pure Lines: From Nineteenth-Century Biology to Twentieth-Century Genetics
Article
Ute Deichmann;
(2015)
Chromatin: Its history, current research, and the seminal researchers and their philosophy
Article
Veronica Vivona;
Luca Lepore;
Giorgia Bilato;
Lorenzo Mortara;
Andrea De Lerma Barbaro;
(2024)
The history of discovery of Interleukin-1: a fundamental cytokine of the innate immune response
Book
Mathias Grote;
(2019)
Membranes to Molecular Machines: Active Matter and the Remaking of Life
Book
Bernardino Fantini;
Fabrizio Rufo;
(2017)
Il codice della vita. Una storia della genetica tra scienza e bioetica
Article
Marc Henry;
(2021)
Thermodynamics of Life
Article
Reynolds, Andrew;
(2007)
The Cell's Journey: From Metaphorical to Literal Factory
Article
Hans-Jürgen Apell;
(2019)
Finding Na,K-ATPase II - From fluxes to ion movements
Article
Bungener, Patrick;
Buscaglia, Marino;
(2003)
Early Connection between Cytology and Mendelism: Michael F. Guyer's Contribution
Article
David R. Singleton;
Rivers Singleton;
(2017)
Remembering Our Forebears: Albert Jan Kluyver and the Unity of Life
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Substantia: An International Journal of the History of Chemistry
Comptes Rendus Biologies
Endeavour: Review of the Progress of Science
Historical Records of Australian Science
Be the first to comment!