Dioscorides's De materia medica from the first century AD was for about 1,800 years the most influential work and prime source in all matters concerning drugs and pharmacy. Originally written in Greek, the book was soon translated into Latin, thereby changing its structure from a systematic arrangement in five books according to the internal relationship of the drugs to a simply alphabetical order by the first letter of the name. Such an alphabetical order was also retained in the first printed version of the work in 1478. This edition was praised by recent researchers because of its supposed new material, by others, however, it was criticized severely with respect to its general set-up. The present paper discusses both opinions and substantiates some other neglected details regarding the 1478 edition. Besides the 1478 edition the amended new edition from 1512 is analysed too.
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