Book ID: CBB401616956

Model Systems in Biology: History, Philosophy, and Practical Concerns (2022)

unapi

Georg Striedter (Author)


MIT Press


Publication Date: 2022
Physical Details: 304
Language: English

In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively.

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Citation URI
https://data.isiscb.org/isis/citation/CBB401616956/

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Authors & Contributors
Schlünder, Martina
Reiß, Christian
Ramsden, Edmund
Leonelli, Sabina
Kirk, Robert
Huentelmann, Axel C.
Concepts
Experimental organisms
Animal experimentation
Standards and standardization
Medical research
Animals
Laboratory techniques and procedures
Time Periods
20th century
20th century, late
21st century
20th century, early
19th century
Early modern
Places
United States
Great Britain
United Kingdom
Washington (state, U.S.)
Sweden
Germany
Institutions
Königlich Preußischen Institut für experimentelle Therapie
Georg Speyer-Haus
International Committee on Laboratory Animals
Hanford Nuclear Site (Washington)
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