In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively.
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Experimenting with Humans and Animals: From Aristotle to CRISPR
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Pig Mentations: Race and Face in Radiobiology
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Ankeny, Rachel A.;
Leonelli, Sabina;
Nelson, Nicole C.;
Ramsden, Edmund;
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Making Organisms Model Human Behavior: Situated Models in North-American Alcohol Research, since 1950
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Karen A. Rader;
(2022)
Reflections on Making Mice (2004)
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Article
Angela N. H. Creager;
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Model Organisms Unbound
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Per-Anders Svärd;
Helena Tinnerholm Ljungberg;
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Fetal and animal research in Sweden: The construction of viable lives in regulatory policy debates, 1970–1980
(/isis/citation/CBB965696186/)
Article
Gail Davies;
(2021)
Locating the ‘culture wars’ in laboratory animal research: National constitutions and global competition
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Schlünder, Martina;
(2012)
Wissens-Hunger im Stall: Die Entstehung von Knochen-Schafen als Versuchstiere in der Unfallchirurgie
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Kirk, Robert G. W.;
(2012)
“Standardization through Mechanization”: Germ-Free Life and the Engineering of the Ideal Laboratory Animal
(/isis/citation/CBB001230796/)
Article
Pemberton, Neil;
(2013)
The Bloodhound's Nose Knows? Dogs and Detection in Anglo-American Culture
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Book
Endersby, Jim;
(2007)
A Guinea Pig's History of Biology: The Plants and Animals Who Taught Us the Facts of Life
(/isis/citation/CBB000774282/)
Article
Kirk, Robert G. W.;
(2010)
A Brave New Animal for a Brave New World: The British Laboratory Animals Bureau and the Constitution of International Standards of Laboratory Animal Production and Use, circa 1947--1968
(/isis/citation/CBB000954051/)
Article
Schlünder, Martina;
Reiß, Christian;
Hüntelmann, Axel C.;
Bauer, Susanne;
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Cakes und Candies -- Zur Geschichte der Ernährung von Versuchstieren
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Michael R. Dietrich;
Rachel A. Ankeny;
Nathan Crowe;
Sara Green;
Sabina Leonelli;
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How to choose your research organism
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Volker Roelcke;
(2022)
The animal model of human disease as a core concept of medical research: Historical cases, failures, and some epistemological considerations
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Reiß, Christian;
(2012)
Wie die Zoologie das Füttern lernte. Die Ernährung von Tieren in der Zoologie im 19. Jahrhundert
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Meunier, Robert;
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Stages in the Development of a Model Organism as a Platform for Mechanistic Models in Developmental Biology: Zebrafish, 1970--2000
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Chapter
Ramsden, Edmund;
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Travelling Facts about Crowded Rats: Rodent Experimentation and the Human Sciences
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Article
Marie, Jenny;
(2008)
For Science, Love and Money: The Social Worlds of Poultry and Rabbit Breeding in Britain, 1900--1940
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Article
Hüntelmann, Axel C.;
(2012)
Füttern und gefüttert werden. Versorgungskreisläufe und Nahrungsregimes im Königlich Preußischen Institut für experimentelle Therapie, ca. 1900 bis 1910
(/isis/citation/CBB001211074/)
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