Article ID: CBB351217129

Phenylbutazone (Bute, PBZ, EPZ): One Drug across Two Species (2018)

unapi

In this article we explore the different trajectories of this one drug,phenylbutazone, across two species, humans and horses in the period 1950–2000. Theessay begins by following the introduction of the drug into human medicine in theearly 1950s. It promised to be a less costly alternative to cortisone, one of the“wonder drugs” of the era, in the treatment of rheumatic conditions. Both drugsappeared to offer symptomatic relief rather than a cure, and did so with the risk ofside effects, which with phenylbutazone were potentially so severe that it waseventually banned from human use, for all but a few diseases, in the early 1980s.Phenylbutazone had been used with other animals for many years without the sameissues, but in the 1980s its uses in veterinary medicine, especially in horses, cameunder increased scrutiny, but for quite different reasons. The focus was primarilythe equity, economics, and ethics of competition in equine sports, with differencesin cross-species biology and medicine playing a secondary role. The story ofphenylbutazone, a single drug, shows how the different biologies and social roles ofits human/animal subjects resulted in very different and changing uses. While thedrug had a seemingly common impact on pain and inflammation, there wereinter-species differences in the drug’s metabolism, the conditions treated, dosages,and, crucially, in intended clinical outcomes and perceptions of its benefits andrisks.

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Authors & Contributors
Christoph D. D. Rupprecht
Laÿna Droz
Romaric Jannel
Bickford, Andrew
Anna Wienhues
Maris, Ronald W.
Concepts
Pharmacology
Pharmacy
Pharmaceutical industry
Medicine
Multispecies studies; interspecies studies
Psychotropic drugs
Time Periods
20th century, late
21st century
20th century
13th century
Places
United States
Nepal
Baltimore (Maryland, U.S.)
New Zealand
Germany
Europe
Institutions
Human Genome Project
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