Article
ID: CBB337343238

Sir Frederick Grant Banting und die Entdeckung des Insulins (Sir Frederick Grant Banting and the discovery of insulin) (2020)

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Diabetes Medicine Insulin 19th century Canada Banting, Frederick Grant

Der Diabetes gehörte über Jahrtausende zu den Erkrankungen, die man anhand untrüglicher Kennzeichen – wie unstillbaren Durst, erhöhten Harndrang und Mattheit – zwar erkennen konnte, denen man aber schicksalhaft ausgeliefert war. Im 19. Jahrhundert wurde durch histologische Untersuchungen und physiologische Experimente zunehmen klar, dass die Bauchspeicheldrüse und die von Langerhans beschriebenen Inselzellen eine fundamentale Bedeutung bei der Pathogenese haben. Basierend auf diesen Erkenntnissen ging der kanadische Mediziner Banting vor 100 Jahren das Problem gezielt an – mit der Isolierung des zuvor nur postulierten Insulins und ersten Anwendungen machte er den Diabetes zu einer therapierbaren Erkrankung – ein Durchbruch, dem bis heute Millionen Menschen ihr Leben verdanken. (For thousands of years, diabetes was one of those diseases that could be recognized by means of unmistakable signs - such as unquenchable thirst, increased urge to urinate and lassitude - but to which one was fatefully at the mercy. In the 19th century, histological studies and physiological experiments made it increasingly clear that the pancreas and the islet cells described by Langerhans played a fundamental role in pathogenesis. Based on these findings, the Canadian physician Banting specifically addressed the problem 100 years ago - with the isolation of insulin, which had previously only been postulated, and its first applications, he made diabetes a treatable disease - a breakthrough to which millions of people still owe their lives today.

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Authors & Contributors
Sinding, Christiane
Rutty, Christopher J.
Avery, Donald H.
Best, Henry B. M.
Bliss, Michael
Cassier, Maurice
Journals
Bulletin of the History of Medicine
Social History of Medicine
Canadian Bulletin of Medical History/Bulletin Canadienne d'Histoire de la Medecine
Histoire des Sciences Médicales
History and Technology
Indian Journal of History of Science
Publishers
University of Manitoba Press
University of Toronto Press
Oxford University Press
Tonawanda
University of North Carolina Press
Concepts
Diabetes
Insulin
Medicine
Disease and diseases
Pharmaceutical industry
Public health
People
Banting, Frederick Grant
Best, Charles Herbert
Bouchardat, A. (Apollinaire)
Noble, Edward Clark
Osler, William
FitzGerald, John G.
Time Periods
20th century
20th century, late
19th century
20th century, early
21st century
Ancient
Places
Canada
United States
India
East Germany
Paris (France)
New Orleans (Louisiana, U.S.)
Institutions
University of Toronto
Eli Lilly and Company
Connaught Laboratories (Canada)
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