Article
ID: CBB297517123

Franklin Delano Roosevelt’s (FDR’s) (1882–1945) 1921 Neurological Disease Revisited; the Most Likely Diagnosis Remains Guillain–Barré Syndrome (2016)

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Guillain–Barré Syndrome Neurological diseases 20th century 19th century United States Roosevelt, Franklin D.

In 2003, we published evidence that the most likely cause of FDR’s 1921 neurological disease was Guillain–Barré syndrome. Afterwards, several historians and neurologists stated in their publications that FDR had paralytic poliomyelitis. However, significant criticism of our article or new support for that diagnosis was not revealed. One critic claimed that FDR’s cerebrospinal fluid indicated poliomyelitis, but we did not find evidence that a lumbar puncture was performed. The diagnosis of FDR’s neurological disease still depends upon documented clinical abnormalities. His age, prolonged symmetric ascending paralysis, transient numbness, protracted dysaesthesia (pain on slight touch), facial paralysis, bladder and bowel dysfunction, and absence of meningismus are typical of Guillain–Barré syndrome and are inconsistent with paralytic poliomyelitis. FDR’s prolonged fever was atypical for both diseases. Finally, permanent paralysis, though commoner in paralytic poliomyelitis, is frequent in Guillain–Barré syndrome. Thus, the clinical findings indicate the most likely diagnosis in FDR’s case remains Guillain–Barré syndrome.

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Authors & Contributors
David Kieran
Conti-Brown, Peter
Zoe M. Adams
Joseph J. Fins
Alexander, Benjamin F.
Sean H. Vanatta
Journals
Journal of the History of the Neurosciences
Journal of Medical Biography
Technology and Culture
Journal of the History of Medicine and Allied Sciences
History of Psychology
Business History Review
Publishers
University of Cambridge (United Kingdom)
Regent University
University of Tennessee Press
University of Rochester Press
New York University Press
Johns Hopkins University Press
Concepts
Neurological diseases
Medicine
Poliomyelitis
Neurology
Disease and diseases
Science and society
People
Roosevelt, Franklin D.
Lahey, Frank Howard
Hogben, Lancelot Thomas
Huxley, Julian Sorell
Rogers, Carl R.
Ramanujan, Srinivasa
Time Periods
20th century
19th century
20th century, early
21st century
18th century
Places
United States
Potsdam (Germany)
Southern states (U.S.)
Netherlands
North Carolina (U.S.)
Great Britain
Institutions
New Deal (1933-1939)
United States. Farm Security Administration
United States Department of Agriculture (USDA)
Civilian Conservation Corps (U.S.)
Tennessee Valley Authority
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