Article ID: CBB297517123

Franklin Delano Roosevelt’s (FDR’s) (1882–1945) 1921 Neurological Disease Revisited; the Most Likely Diagnosis Remains Guillain–Barré Syndrome (2016)

unapi

In 2003, we published evidence that the most likely cause of FDR’s 1921 neurological disease was Guillain–Barré syndrome. Afterwards, several historians and neurologists stated in their publications that FDR had paralytic poliomyelitis. However, significant criticism of our article or new support for that diagnosis was not revealed. One critic claimed that FDR’s cerebrospinal fluid indicated poliomyelitis, but we did not find evidence that a lumbar puncture was performed. The diagnosis of FDR’s neurological disease still depends upon documented clinical abnormalities. His age, prolonged symmetric ascending paralysis, transient numbness, protracted dysaesthesia (pain on slight touch), facial paralysis, bladder and bowel dysfunction, and absence of meningismus are typical of Guillain–Barré syndrome and are inconsistent with paralytic poliomyelitis. FDR’s prolonged fever was atypical for both diseases. Finally, permanent paralysis, though commoner in paralytic poliomyelitis, is frequent in Guillain–Barré syndrome. Thus, the clinical findings indicate the most likely diagnosis in FDR’s case remains Guillain–Barré syndrome.

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Authors & Contributors
David Kieran
Conti-Brown, Peter
Zoe M. Adams
Joseph J. Fins
Alexander, Benjamin F.
Sean H. Vanatta
Concepts
Neurological diseases
Medicine
Poliomyelitis
Neurology
Disease and diseases
Science and society
Time Periods
20th century
19th century
20th century, early
21st century
18th century
Places
United States
Potsdam (Germany)
Southern states (U.S.)
Netherlands
North Carolina (U.S.)
Great Britain
Institutions
New Deal (1933-1939)
United States. Farm Security Administration
United States. Department of Agriculture
Civilian Conservation Corps (U.S.)
Tennessee Valley Authority
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