Sankaran, Neeraja (Author)
In 1965, French microbiologist André Lwoff was awarded the Nobel Prize in Physiology or Medicine for his work on lysogeny—one of the two types of viral life cycles—which resolved a contentious debate among scientists about the nature of viruses. A Tale of Two Viruses is the first study of medical virology to compare the history of two groups of medically important viruses—bacteriophages, which infect bacteria, and sarcoma agents, which cause cancer—and the importance of Lwoff’s discovery to our modern understanding of what a virus is. Although these two groups of viruses may at first glance appear to have little in common, they share uniquely parallel histories. The lysogenic cycle, unlike the lytic, enables viruses to replicate in the host cell without destroying it and to remain dormant in a cell’s genetic material indefinitely, or until induced by UV radiation. But until Lwoff’s discovery of the mechanism of lysogeny, microbiologist Félix d’Herelle and pathologist Peyton Rous, who themselves first discovered and argued for the viral identity of bacteriophages and certain types of cancer, respectively, faced opposition from contemporary researchers who would not accept their findings. By following the research trajectories of the two virus groups, Sankaran takes a novel approach to the history of the development of the field of medical virology, considering both the flux in scientific concepts over time and the broader scientific landscapes or styles that shaped those ideas and practices.
...MoreReview K.-B.G. Scholthof (2021) Review of "A Tale of Two Viruses: Parallels in the Research Trajectories of Tumor and Bacterial Viruses". The FASEB Journal.
Review Martin Bush (2022) Review of "Into the Loneliness: The Unholy Alliance of Ernestine Hill and Daisy Bates". Historical Records of Australian Science (pp. 72-77).
Review Mauro Mandrioli (2021) Review of "A Tale of Two Viruses: Parallels in the Research Trajectories of Tumor and Bacterial Viruses". Nuncius: Annali di Storia della Scienza (pp. 237-239).
Review Hyung Wook Park (2022) Review of "A Tale of Two Viruses: Parallels in the Research Trajectories of Tumor and Bacterial Viruses". Isis: International Review Devoted to the History of Science and Its Cultural Influences (pp. 458-459).
Article
Sankaran, Neeraja;
(2014)
When Viruses Were Not in Style: Parallels in the Histories of Chicken Sarcoma Viruses and Bacteriophages
(/isis/citation/CBB001421657/)
Article
Dmitriy Myelnikov;
(2020)
Creature Features: The Lively Narratives of Bacteriophages in Soviet Biology and Medicine
(/isis/citation/CBB744503683/)
Article
Morgan, Gregory J.;
(2006)
Why There Was a Useful Plausible Analogy between Geodesic Domes and Spherical Viruses
(/isis/citation/CBB000774682/)
Article
Patrick Forterre;
(2016)
To be or not to be alive: How recent discoveries challenge the traditional definitions of viruses and life
(/isis/citation/CBB294214713/)
Article
Fisher, Susie;
(2010)
Not Beyond Reasonable Doubt: Howard Temin's Provirus Hypothesis Revisited
(/isis/citation/CBB001022393/)
Article
Rogers, George E.;
Elliott, William H.;
(2008)
Robert Henry Symons 1934--2006
(/isis/citation/CBB000932004/)
Article
Azzone, Giovanni Felice;
(2001)
Il caso e la necessità: la duplice identità degli organismi viventi
(/isis/citation/CBB000770069/)
Article
Neeraja Sankaran;
(2020)
Introduction: Diversifying the Historiography of Bacteriophages
(/isis/citation/CBB568902513/)
Chapter
Summers, William C.;
(2005)
Bacteriophage Research: Early History
(/isis/citation/CBB001221094/)
Book
Cornwall, Claudia;
(2013)
Catching Cancer: The Quest for Its Viral and Bacterial Causes
(/isis/citation/CBB001213235/)
Article
Báguena Cervellera, M. J.;
(2009)
Estudios epidemiológicos y virológicos sobre la poliomielitis en Valencia (1959--1969)
(/isis/citation/CBB000931886/)
Article
Zdravko Lacković;
Karlo Toljan;
(2020)
Vladimir Sertić: Forgotten Pioneer of Virology and Bacteriophage Therapy
(/isis/citation/CBB098825987/)
Article
Eugene V. Koonin;
Petro Starokadomskyy;
(2016)
Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question
(/isis/citation/CBB397015597/)
Article
Marcum, James A.;
(2002)
From Heresy to Dogma in Accounts of Opposition to Howard Temin's DNA Provirus Hypothesis
(/isis/citation/CBB000501150/)
Article
M. H. V. van Regenmortel;
(2016)
The metaphor that viruses are living is alive and well, but it is no more than a metaphor
(/isis/citation/CBB997086708/)
Article
Bertolaso, Marta;
(2009)
Towards an Integrated View of the Neoplastic Phenomena in Cancer Research
(/isis/citation/CBB000932681/)
Article
Sankaran, Neeraja;
(2008)
Stepping-Stones to One-Step Growth: Frank Macfarlane Burnet's Role in Elucidating the Viral Nature of the Bacteriophages
(/isis/citation/CBB000932000/)
Book
Gregory J. Morgan;
(2022)
Cancer Virus Hunters: A History of Tumor Virology
(/isis/citation/CBB284978916/)
Article
Chastel, Claude;
(2006)
Egypte moderne et histoire de la microbiologie: de l'expédition de Bonaparte à nos jours
(/isis/citation/CBB000931794/)
Book
Holmes, Frederic Lawrence;
Summers, William C.;
(2006)
Reconceiving the Gene: Seymour Benzer's Adventures in Phage Genetics
(/isis/citation/CBB000772243/)
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