Article ID: CBB254042473

From morphine to endogenous opioid peptides, e.g., endorphins: the endless quest for the perfect painkiller (2018)

unapi

Opium was known since the Neolithic era and in 5th century wild Papaver use was reported to induce sleep and relieving pain. First active component isolated from Opium was morphine, the paradigm of a natural product discovered 150 years before isolation of endogenous opioid ligands, brain pentapeptide enkephalins. Since then many endorphin peptides and their mode of action were discovered. Native endorphins were characterized thanks to the synthetic antagonist naloxone.

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Authors & Contributors
Lafont, Olivier
Berridge, Virginia
Gootenberg, Paul
Higby, Gregory J.
Kirschke, Martin
Lande, R. Gregory
Journals
Revue d'Histoire de la Pharmacie
Circumscribere: International Journal for the History of Science
Historical Records of Australian Science
History of Psychiatry
Journal of the Economic and Social History of the Orient
Medical History
Publishers
GNT
IASP Press
Oxford University Press
Presses Universitaires de Rennes
UBC Press
Walter de Gruyter
Concepts
Pharmacy
Opium and opium trade
Narcotics and drugs
Medicine
Organic chemistry
Drug use
People
Kastner, Karl Wilhelm Gottlieb
Liebig, Justus von
Scheele, Carl Wilhelm
Sertürner, Friedrich Wilhelm Adam
Sydenham, Thomas
Shaw, Frank
Time Periods
19th century
18th century
20th century
17th century
20th century, early
20th century, late
Places
Asia
United States
Great Britain
Ottoman Empire
Canada
France
Institutions
Universität Bonn
University of Melbourne
Ecole supérieure de pharmacie de Paris
Heidelberg Universität
Nicholas Pty Ltd
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