Watkins, Elizabeth Siegel (Advisor)
Erika Michelle Langer (Author)
This study examines the history of yeast hereditary research out of the fermentation industries and into the genetics laboratory, where a single-celled fungus underwent material, technical, and conceptual transformations to become an experimental system, an ideal eukaryotic cell, a model organism, and a genetically-engineered cell factory with which to advance the molecularization of human health and disease. The work draws from new and existing oral histories and archives across academic and commercial institutions to follow the development, circulation, and use of Saccharomyces cerevisiae wild-type yeast strain S288C and its mutants along with their accompanying experimental practices and politics in a range of international settings. The rise of the yeast model organism in U.S. biomedical research is shown to have been a political application of eukaryotic molecular biology with particular utility, for example, in accessing basic science funding for cancer research at the level of the cell. A final case study of yeast-made recombinant Hepatitis B vaccine reveals how the biotech industry manufactured therapeutics out of human molecules on the rise of eukaryotic molecular biology.
...More
Article
Deichmann, Ute;
(2009)
Chemistry and the Engineering of Life around 1900: Research and Reflections by Jacques Loeb
(/isis/citation/CBB001230120/)
Book
Mathias Grote;
(2019)
Membranes to Molecular Machines: Active Matter and the Remaking of Life
(/isis/citation/CBB578630199/)
Chapter
Gissis, Snait B.;
Jablonka, Eva;
(2011)
The Exclusion of Soft (“Lamarckian”) Inheritance from the Modern Synthesis
(/isis/citation/CBB001500089/)
Book
Michel Morange;
(2020)
The Black Box of Biology: A History of the Molecular Revolution
(/isis/citation/CBB035364586/)
Book
Galperin, Charles;
Gilbert, Scott F.;
Hoppe, Brigitte;
(1999)
Fundamental Changes in Cellular Biology in the 20th Century: Biology of Development, Chemistry and Physics in the Life Sciences
(/isis/citation/CBB000700922/)
Article
Kurt Plischke;
Alfons Labisch;
(2017)
Zur Wissenschaftsgeschichte des biologischen Terminus ,Gen'. Ein Beitrag zur Modellbildung in der Biologie
(/isis/citation/CBB613565817/)
Article
Müller-Wille, Staffan;
(2007)
Hybrids, Pure Cultures, and Pure Lines: From Nineteenth-Century Biology to Twentieth-Century Genetics
(/isis/citation/CBB000831420/)
Chapter
Matthis Krischel;
Frank Kressing;
Heiner Fangerau;
(2009)
Computergestützte Netzwerkanalyse in Biologie, Sprach- und Geschichtswissenschaft
(/isis/citation/CBB581773102/)
Article
Bensaude-Vincent, Bernadette;
(2009)
Biomimetic Chemistry and Synthetic Biology: A Two-way Traffic across the Borders
(/isis/citation/CBB001021317/)
Chapter
Jeffrey Allan Johnson;
(2016)
From Bio-organic Chemistry to Molecular and Synthetic Biology: Fulfilling Emil Fischer’s Dream
(/isis/citation/CBB095124609/)
Article
Talia Dan-Cohen;
(September 2016)
Ignoring Complexity: Epistemic Wagers and Knowledge Practices among Synthetic Biologists
(/isis/citation/CBB599343715/)
Book
Sophia Roosth;
(2017)
Synthetic: How Life Got Made
(/isis/citation/CBB671229087/)
Article
Sara Giordano;
(May 2018)
New Democratic Sciences, Ethics, and Proper Publics
(/isis/citation/CBB369714455/)
Article
Peretó, J.;
Catalá-Gorgues, J. I.;
(2007)
The Renaissance of Synthetic Biology
(/isis/citation/CBB001023444/)
Article
Larry Au;
(2023)
Ethical choreography in China’s Human Gene Editing controversy
(/isis/citation/CBB421942539/)
Article
Per-Anders Svärd;
Helena Tinnerholm Ljungberg;
(2021)
Fetal and animal research in Sweden: The construction of viable lives in regulatory policy debates, 1970–1980
(/isis/citation/CBB965696186/)
Article
Mathangi Krishnamurthy;
(March 2020)
Navigating the Body Multiple: Biomedicine, Genetics, and Sex/Gender in the Lives of CAH Patients (Research Note)
(/isis/citation/CBB524326627/)
Article
Simon Lohse;
(2021)
Scientific inertia in animal-based research in biomedicine
(/isis/citation/CBB124857110/)
Article
Hannah Landecker;
(2016)
It is what it eats: Chemically defined media and the history of surrounds
(/isis/citation/CBB598422047/)
Article
Bensaude-Vincent, Bernadette;
(2009)
Synthetic Biology as a Replica of Synthetic Chemistry? Uses and Misuses of History
(/isis/citation/CBB001230118/)
Be the first to comment!