Article ID: CBB219354754

Yeast Sequencing: “Network” Genomics and Institutional Bridges (2022)

unapi

This paper examines the model of network genomics pioneered in the late 1980s and adopted in the European Commission-led Yeast Genome Sequencing Project (YGSP). It contrasted with the burgeoning large-scale center model being developed in the United States to sequence the yeast genome, chiefly as a pilot for tackling the human genome. We investigate the operation and connections of the two models by exploring a co-authorship network that captures different types of sequencing practices. In our network analysis, we focus on institutions that bridge both the European and American yeast whole-genome sequencing projects, and such concerted projects with non-concerted sequencing of yeast DNA. The institutions include two German biotechnology companies and Biozentrum, a research institute at Universität Basel that adopted yeast as a model to investigate cell biochemistry and molecular biology. Through assessing these bridging institutions, we formulate two analytical distinctions: between proximate and distal, and directed and undirected sequencing. Proximate and distal refer to the extent that intended users of DNA sequence data are connected to the generators of that data. Directed and undirected capture the extent to which sequencing was part of a specific research program. The networked European model, as mobilized in the YGSP, enabled the coexistence and cooperation of institutions exhibiting different combinations of these characteristics in contrast with the more uniformly distal and undirected large-scale centers. This contributes to broadening the historical boundaries of genomics and presenting a thicker historiography, one that inextricably meshes genomics with the trajectories of biotechnology and cell biology. This essay is part of a special issue entitled The Sequences and the Sequencers: A New Approach to Investigating the Emergence of Yeast, Human, and Pig Genomics, edited by Miguel García-Sancho and James Lowe.

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Associated with

Article James Lowe; Rhodri Leng; Gil Viry; Mark Wong; Niki Vermeulen; Miguel García-Sancho (2022) The Bricolage of Pig Genomics. Historical Studies in the Natural Sciences (pp. 401-442). unapi

Article Miguel García-Sancho; Rhodri Leng; Gil Viry; Mark Wong; Niki Vermeulen; James Lowe (2022) The Human Genome Project as a Singular Episode in the History of Genomics. Historical Studies in the Natural Sciences (pp. 320-360). unapi

Article James Lowe; Miguel García-Sancho; Rhodri Leng; Mark Wong; Niki Vermeulen; Gil Viry (2022) Across and within Networks: Thickening the History of Genomics. Historical Studies in the Natural Sciences (pp. 443-475). unapi

Article Rhodri Leng; Gil Viry; Miguel García-Sancho; James Lowe; Mark Wong; Niki Vermeulen (2022) The Sequences and the Sequencers: What Can a Mixed-Methods Approach Reveal about the History of Genomics?. Historical Studies in the Natural Sciences (pp. 277-319). unapi

Citation URI
https://data.isiscb.org/isis/citation/CBB219354754/

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Authors & Contributors
James Lowe
García-Sancho, Miguel
Gil Viry
Mark Wong
Rhodri Ivor Leng
Vermeulen, Niki
Journals
Historical Studies in the Natural Sciences
Notes and Records: The Royal Society Journal of the History of Science
Journal of the History of Biology
Studies in History and Philosophy of Science
East Asian Science, Technology and Society: An International Journal
Canadian Bulletin of Medical History/Bulletin Canadienne d'Histoire de la Medecine
Publishers
Springer Nature
University of California, Irvine
Yale University Press
Cambridge University Press
Concepts
Scientific communities; interprofessional relations
Scientific collaboration
Social networks
Genomics
Molecular sequencing
Cross-national interaction
People
Eschenmoser, Albert
Will, Heinrich
Novikov, Evgeny
Jōkichi Takamine
Stewart, R. W.
Warington, Robert
Time Periods
20th century, late
21st century
20th century
20th century, early
19th century
Places
Germany
China
Great Britain
South Korea
Moscow (Russia)
Canada
Institutions
Human Genome Project
Belgian Nuclear Research Centre (SCK CEN)
Obukhov Institute of Atmospheric Physics
Royal Society of London
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