Article ID: CBB214010324

Finding Na,K-ATPase II - From fluxes to ion movements (2019)

unapi

After identification of the Na,K-ATPase as active ion transporter that maintains the Na+ and K+ concentration gradient across the membrane of virtually all animal cells, a long history of mechanistic studies began in which enzyme activity and ion-transport were intensively investigated. A basis for detailed understanding was laid in the so-called Post-Albers pump cycle. Developing new experimental techniques allowed the determination of different flux modes, the analysis of the kinetics of enzyme phosphorylation and dephosphorylation as well as of the transport of Na+and K+ ions across the membrane. The accumulation of results from transport studies allowed the proposal of the gated channel concept that turned out to be a successful approach to explain the transport-related experimental findings. Eventually, it found its counterpart in the high-resolution structure of the ion pump. Recently it turned out that simple mutations of the Na,K-ATPase are the cause of several diseases.

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Authors & Contributors
Henry, Marc
Zon, Gerald
Apell, Hans-Jürgen
Holmes, Allyson M.
Campaner, Raffaella
Blaiseau, Pierre-Louis
Journals
Substantia: An International Journal of the History of Chemistry
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Vesalius
Science and Education
Minerva: A Review of Science, Learning and Policy
Journal of the History of Biology
Publishers
Fondazione Museo Storico del Trentino
Diaphanes
Carocci Editore
Australian Scholarly Publishing
Concepts
Medicine
Biology
Physiology
Chemistry
Biochemistry
Physics
People
Jacob, François
Yukawa, Hideki
Redi, Francesco
Mosso, Angelo
Monod, Jacques
Malpighi, Marcello
Time Periods
20th century
21st century
19th century
Early modern
20th century, late
18th century
Places
Germany
Europe
Australia
United States
Spain
Japan
Institutions
Adelaide University
Turin. Università
University of Melbourne
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