Article ID: CBB214010324

Finding Na,K-ATPase II - From fluxes to ion movements (2019)


After identification of the Na,K-ATPase as active ion transporter that maintains the Na+ and K+ concentration gradient across the membrane of virtually all animal cells, a long history of mechanistic studies began in which enzyme activity and ion-transport were intensively investigated. A basis for detailed understanding was laid in the so-called Post-Albers pump cycle. Developing new experimental techniques allowed the determination of different flux modes, the analysis of the kinetics of enzyme phosphorylation and dephosphorylation as well as of the transport of Na+and K+ ions across the membrane. The accumulation of results from transport studies allowed the proposal of the gated channel concept that turned out to be a successful approach to explain the transport-related experimental findings. Eventually, it found its counterpart in the high-resolution structure of the ion pump. Recently it turned out that simple mutations of the Na,K-ATPase are the cause of several diseases.

Citation URI

Similar Citations

Book Raffaella Campaner; Carlo Gabbani; (2023)
Realismo e antirealismo nelle scienze: Un percorso multidisciplinare (/isis/citation/CBB608622537/)

Book Rothenberg, Albert; (2015)
Flight from Wonder: An Investigation of Scientific Creativity (/isis/citation/CBB001510110/)

Article Pierre Louis Blaiseau; Allyson M. Holmes; (2021)
Diauxic Inhibition: Jacques Monod's Ignored Work (/isis/citation/CBB929908273/)

Article Hans-Jürgen Apell; (2018)
Finding Na,K-ATPase: I - From Cell to Molecule (/isis/citation/CBB428130959/)

Essay Review Cohen, Seymour S.; (2000)
A Guide to the History of Biochemistry (/isis/citation/CBB000111008/)

Article Low, Morris; (2001)
From Einstein to Shirakawa: The Nobel Prize in Japan (/isis/citation/CBB000102580/)

Book Hagner, Michael; Laubichler, Manfred Dietrich; (2006)
Der Hochsitz des Wissens: Das Allgemeine als wissenschaftlicher Wert (/isis/citation/CBB001021520/)

Article Losano, Gianni; Pinotti, Oreste; (2000)
Physiology at the University of Turin from the Unification of Italy to the End of the Twentieth Century (/isis/citation/CBB000932397/)

Book Massimiano Bucchi; Luca Ciancio; Ariane Dröscher; (2015)
L'esperimento della storia. Saggi in onore di Renato G. Mazzolini (/isis/citation/CBB236977309/)

Article Rogers, George E.; (2013)
William Herdman Elliott 1925--2012 (/isis/citation/CBB001211869/)

Book Flesch, Juliet; (2012)
Life's Logic: 150 Years of Physiology at the University of Melbourne (/isis/citation/CBB001252491/)

Article Marc Henry; (2021)
Thermodynamics of Life (/isis/citation/CBB851479700/)

Article Barry W. Ninham; (2017)
The Biological/Physical Sciences Divide, and the Age of Unreason (/isis/citation/CBB003736245/)

Article Bernadette Bensaude Vincent; (2016)
From Self-Organization to Self-Assembly: A New Materialism? (/isis/citation/CBB472551413/)

Article Jack S. Cohen; (2021)
History of Research on Antisense Oligonucleotide Analogs (/isis/citation/CBB450691525/)

Article Gerald Zon; (2021)
Chemistry, Cyclophosphamide, Cancer Chemotherapy, and Serendipity: Sixty Years On (/isis/citation/CBB089015962/)

Authors & Contributors
Henry, Marc
Zon, Gerald
Apell, Hans-Jürgen
Holmes, Allyson M.
Campaner, Raffaella
Blaiseau, Pierre-Louis
Substantia: An International Journal of the History of Chemistry
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Science and Education
Minerva: A Review of Science, Learning and Policy
Journal of the History of Biology
Fondazione Museo Storico del Trentino
Carocci Editore
Australian Scholarly Publishing
Jacob, François
Yukawa, Hideki
Redi, Francesco
Mosso, Angelo
Monod, Jacques
Malpighi, Marcello
Time Periods
20th century
21st century
19th century
Early modern
20th century, late
18th century
United States
Adelaide University
Turin. Università
University of Melbourne

Be the first to comment!

{{ comment.created_by.username }} on {{ comment.created_on | date:'medium' }}

Log in or register to comment