Article ID: CBB176490993

Human Germline Editing: A Historical Perspective (2017)

unapi

The development of the genome editing system called CRISPR–Cas9 has opened a huge debate on the possibility of modifying the human germline. But the types of changes that could and/or ought to be made have not been discussed. To cast some light on this debate, I will describe the story of the CRISPR–Cas9 system. Then, I will briefly review the projects for modification of the human species that were discussed by biologists throughout the twentieth century. Lastly, I will show that for plenty of reasons, both scientific and societal, germline modification is no longer a priority for our societies.

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Authors & Contributors
Evans, John H.
Coeckelbergh, Mark
Fabrizio Rufo
Battisti, Davide
Leitão, Henrique
Delgado, Abigail Nieves
Concepts
Biology and ethics; bioethics
Genetics
Genetic engineering
DNA; RNA
Biotechnology
Science and ethics
Time Periods
21st century
20th century
20th century, late
19th century
Places
San Francisco (California)
United States
Portugal
Latin America
Institutions
Instituto Gulbenkian de Ciência (IGC)
Stanford University
Human Genome Project
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