The question of causation in psychiatry is one of the oldest and most difficult in this field. This paper is the first of two published in this journal. First, it traces the development of psychogenic and organogenic views of mental disorders from Pinel until the early twentieth century. This includes the debate as to how a disturbance of function might create a lesion even without a visible pathological trace. The second part of the paper discusses in detail the controversy between functional and organic causes of mental disease. These concepts evolved taking into account psychological factors and also the response of the uninjured parts of the nervous system to trauma of various kinds.
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