Dietrich, Michael R. (Author)
Harman, Oren (Author)
Lamm, Ehud (Author)
Studies in History and Philosophy of Science
Volume: 88
Pages: 237-244
During the 1960s and 1970s population geneticists pushed beyond models of single genes to grapple with the effect on evolution of multiple genes associated by linkage. The resulting models of multiple interacting loci suggested that blocks of genes, maybe even entire chromosomes or the genome itself, should be treated as a unit. In this context, Richard Lewontin wrote his famous 1974 book The Genetic Basis of Evolutionary Change, which concludes with an argument for considering the entire genome as the unit of selection as a result of linkage. Why did Lewontin and others devote so much intellectual energy to the “complications of linkage” in the 1960s and 1970s? We argue that this attention to linkage should be understood in the context of research on chromosomal inversions and co-adapted gene complexes that occupied mid-century evolutionary genetics. For Lewontin, the complications of linkage were an extension of this chromosomal focus expressed in the new language of models for linkage disequilibrium.
...MoreSimilar Citations
Thesis
Valles, Sean A.;
(2010)
Explaining the Evolution of Common Genetic Disease
Article
Lucas J. Matthews;
(2022)
Half a century later and we're back where we started: How the problem of locality turned in to the problem of portability
Article
Richardson, Sarah S.;
(2012)
Sexing the X: How the X Became the “Female Chromosome”
Book
Wapner, Jessica;
(2013)
The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level
Article
McKnight, Steven;
Beyer, Ann;
Gall, Joseph;
(2012)
Oscar Miller (1925--2012)
Article
Bangham, Jenny;
Chadarevian, Soraya de;
(2014)
Human Heredity after 1945: Moving Populations Centre Stage
Book
Richardson, Sarah S.;
(2013)
Sex Itself: The Search for Male and Female in the Human Genome
Book
Anne Skomorowsky;
(2022)
The Carriers: What the Fragile X Gene Reveals About Family, Heredity, and Scientific Discovery
Article
Skipper, Robert A., Jr.;
(2004)
Calibration of Laboratory Models in Population Genetics
Article
Matthewson, John;
(2011)
Trade-Offs in Model-Building: A More Target-Oriented Approach
Book
Davis, Rowland H.;
(2003)
Microbial Models of Molecular Biology: From Genes to Genomes
Article
María Jesús Santesmases;
(2020)
Standard Making in Cytogenetics: the Manufacture, Circulation and Reproduction of Chromosome Images
Article
Andrew J. Hogan;
(2016)
Making the most of uncertainty: Treasuring exceptions in prenatal diagnosis
Chapter
Chadarevian, Soraya de;
(2013)
Putting Human Genetics on a Solid Basis: Human Chromosome Research, 1950s--1970s
Book
Calvó-Monreal, Xavier;
(2012)
Polímeros e instrumentos. De la química a la biología molecular en Barcelona (1958--1977)
Book
Brady, Catherine;
(2007)
Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA
Article
Alan R. Rushton;
(2021)
Counting human chromosomes before 1960: Preconceptions, perceptions and predilections
Article
Sumiko Hatakeyama;
(2021)
Let Chromosomes Speak: The Cytogenetics Project at the Atomic Bomb Casualty Commission (ABCC)
Article
Miller, Fiona Alice;
(2006)
“Your True and Proper Gender”: The Barr Body as a Good Enough Science of Sex
Thesis
Horton, Dawn Marie;
(2011)
Genetic Epistemology of Science and Scientist in the Human Genome Field
Studies in History and Philosophy of Science
Annals of Science: The History of Science and Technology
HOST: Journal of History of Science and Technology
Journal of the History of Biology
Perspectives on Science
Be the first to comment!