Article ID: CBB124857110

Scientific inertia in animal-based research in biomedicine (2021)

unapi

Despite aspirations to substitute animal experimentation with alternative methods and recent progress in the area of non-animal approaches, such as organoïds and organ(s)-on-a-chip technologies, there is no extensive replacement of animal-based research in biomedicine. In this paper, I will analyse this state of affairs with reference to key institutional and socio-epistemic barriers for the development and use of non-animal approaches in the context of biomedical research in Europe. I will argue that there exist several factors that inhibit change in this context. In particular, there is what I call “scientific inertia”, i.e. a certain degree of conservatism in scientific practice regarding the development and use of non-animal approaches to replace animal experimentation. This type of inertia is facilitated by socio-epistemic characteristics of animal-based research in the life sciences and is a key factor in understanding the status quo in biomedical research. The underlying reasons for scientific inertia have not received sufficient attention in the literature to date because the phenomenon transcends traditional disciplinary boundaries in the study of animal experimentation. This paper addresses this issue and seeks to contribute to a better understanding of scientific inertia by using a methodology that looks at the interplay of institutional, epistemic, and regulatory aspects of animal-based research.

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Authors & Contributors
Brad Bolman
Leonelli, Sabina
Thatcher, Jim
Rommetveit, Kjetil
Patrick Egan
Tempini, Niccolò
Concepts
Experimental organisms
Laboratory techniques and procedures
Laboratory animals
Research methods
Models and modeling in science
Standards and standardization
Time Periods
21st century
20th century
20th century, late
19th century
Early modern
20th century, early
Places
Europe
United States
United Kingdom
Sweden
European Union
Great Britain
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