Article ID: CBB109145764

Antecedents, Development, Adoption, and Application of Duchenne’s Trocar for Histopathologic Studies of Neuromuscular Disorders in the Nineteenth Century (2019)

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Duchenne de Boulogne was one of the founders of clinical neurology. His name has been eponymically linked to the most common form of muscular dystrophy, originally described by him as pseudo-hypertrophic muscular paralysis or myo-sclerotic paralysis. Obtaining muscle biopsy specimens was essential to gain insight about the etiopathogenensis of the disease. Duchenne invented a novel instrument: l’emporte-pièce histologique, also known as “Duchenne’s trocar,” to perform muscle biopsies. Following Duchenne’s design and instructions, a Parisian company, Charrière, constructed the first instrument probably in 1864. That instrument was essential for Duchenne’s description of the histopathological abnormalities typical of pseudo-hypertrophic muscular paralysis. The innovative needle-biopsy technique enabled physicians to analyze the spectrum of pathological changes at varying stages of different neuromuscular diseases. Duchenne’s trocar was a forerunner of several types of modern muscle-biopsy needles. His invention was instrumental in the development of the disciplines of muscle pathology and clinical myology.

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Article Douglas J. Lanska (2019) Instruments in the History of the Clinical Neurosciences. Journal of the History of the Neurosciences (pp. 93-96). unapi

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Authors & Contributors
Reynolds, Edward H.
Eadie, Mervyn J.
Sena, Luigi Massimo
Karakis, Ioannis
Paulina Schulz
Brigo, Francesco
Concepts
Neurology
Neurological diseases
Pathology
Clinical medicine
Medicine
Neurosciences
Time Periods
19th century
20th century
20th century, early
Modern
Ancient
18th century
Places
France
Middle and Near East
England
Naples (Italy)
United States
Italy
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