Article ID: CBB106775788

Biological Regulation: Controlling the System from Within (2015)

unapi

Biological regulation is what allows an organism to handle the effects of a perturbation, modulating its own constitutive dynamics in response to particular changes in internal and external conditions. With the central focus of analysis on the case of minimal living systems, we argue that regulation consists in a specific form of second-order control, exerted over the core (constitutive) regime of production and maintenance of the components that actually put together the organism. The main argument is that regulation requires a distinctive architecture of functional relationships, and specifically the action of a dedicated subsystem whose activity is dynamically decoupled from that of the constitutive regime. We distinguish between two major ways in which control mechanisms contribute to the maintenance of a biological organisation in response to internal and external perturbations: dynamic stability and regulation. Based on this distinction an explicit definition and a set of organisational requirements for regulation are provided, and thoroughly illustrated through the examples of bacterial chemotaxis and the lac-operon. The analysis enables us to mark out the differences between regulation and closely related concepts such as feedback, robustness and homeostasis.

...More
Citation URI
http://data.isiscb.org/isis/citation/CBB106775788/

Similar Citations

Article Bernd Rosslenbroich; (2009)
Patterns and Processes in Macroevolution (/isis/citation/CBB447582249/) unapi

Article Jürgen Bereiter-Hahn; (2009)
Is the Term “Individual” Universal for Organisms? (/isis/citation/CBB291130447/) unapi

Article Anton Kabeshkin; (2017)
Schelling on Understanding Organisms (/isis/citation/CBB510688540/) unapi

Article Boris Demarest; Charles T. Wolfe; (2016)
The Organism as Reality or as Fiction: Buffon and Beyond (/isis/citation/CBB385733908/) unapi

Book Denis Noble; (2016)
Dance to the Tune of Life: Biological Relativity (/isis/citation/CBB656945773/) unapi

Book Ben Martynoga; (2018)
Molecular Tinkering: The Edinburgh Scientists Who Changed the Face of Modern Biology (/isis/citation/CBB777108676/) unapi

Chapter Callebaut, Werner; Müller, Gerd B.; Newman, Stuart A.; (2007)
The Organismic Systems Approach: Evo-Devo and the Streamlining of the Naturalistic Agenda (/isis/citation/CBB001213667/) unapi

Chapter Roberto Serra; (2015)
Proprietà generiche nei sistemi complessi (/isis/citation/CBB320748884/) unapi

Article Creager, Angela N. H.; (2013)
Timescapes of Radioactive Tracers in Biochemistry and Ecology (/isis/citation/CBB001211940/) unapi

Article Constantinos Mekios; (2016)
Organizing principles as tools for bridging the gap between system theory and biological experimentation (/isis/citation/CBB453240305/) unapi

Thesis Eduardo E. Ochoa; (2015)
Complementarity: A Collaborative Tool for the Solution of Complex Problems (/isis/citation/CBB096317128/) unapi

Article Erez Braun; Shimon Marom; (2015)
Universality, complexity and the praxis of biology: Two case studies (/isis/citation/CBB948011358/) unapi

Article Jonathan B. L. Bard; (2017)
C.H. Waddington’s Differences with the Creators of the Modern Evolutionary Synthesis: A Tale of Two Genes (/isis/citation/CBB562199563/) unapi

Book Michel Morange; (2020)
The Black Box of Biology: A History of the Molecular Revolution (/isis/citation/CBB035364586/) unapi

Authors & Contributors
Creager, Angela N. H.
Müller, Gerd B.
Callebaut, Werner
Newman, Stuart A.
Morange, Michel
Cobb, Matthew
Journals
History and Philosophy of the Life Sciences
Annals of the History and Philosophy of Biology
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
British Journal for the History of Philosophy
Publishers
Harvard University Press
Saybrook University
Chronos Verlag
Armando
Cambridge University Press
Arizona State University
Concepts
Systems biology
Organisms
Biology
Philosophy of science
Genetics
Ecology
People
Waddington, Conrad Hal
Jung, Carl Gustav
Bard, Jonathan B. L.
Buffon, Georges Louis Leclerc de
Schelling, Friedrich Wilhelm Joseph von
Clements, Frederic Edward
Time Periods
20th century
21st century
20th century, late
18th century
Places
Switzerland
France
China
Edinburgh
Institutions
Human Genome Project
Comments

Be the first to comment!

{{ comment.created_by.username }} on {{ comment.created_on | date:'medium' }}

Log in or register to comment