Thesis ID: CBB001567664

From Dyspepsia to Helicobacter: A History of Peptic Ulcer Disease (cited 2014)

unapi

This thesis is a historical study of peptic ulcer disease from the sixth decade of the 1760-2000eighteenth century until the end of the twentieth. Symptoms of dyspepsia or indigestion have affected more than twenty percent of the British population for most of that period and attracted the involvement of many medical practitioners and others with the provision of health care. Within this group of symptomatic dyspeptic patients were to be found gastric and duodenal ulcers which were capable of causing serious health problems. However the prevalence of stomach and duodenal peptic ulcers has declined markedly during the time course of this thesis and now they are relatively uncommon. Although peptic ulcers may still have a fatal outcome, they now are considered to be curable conditions for the majority of patients who suffer from them in the developed world.   This thematic history of gastric and duodenal ulcer examines how medical practitioners worked in a changing climate of novel ideas about disease, often aided or driven by technological developments, from the nineteenth century onwards. It begins with a humoural approach to the understanding of disease, which concentrated upon a patient¿s personality, lifestyle choices and circumstances but this was gradually displaced from the end of the eighteenth century by the clinico-anatomical approach, which sought to identify a specific lesion as the `seat¿ of the disease. In the nineteenth century, the discoveries of pathology, physiology, chemistry and bacteriology became incorporated in clinical medical practice, involving the laboratory in the investigation and treatment of many diseases. In the twentieth century, medical research became rooted in experimentation using scientific technology and engineering to equip investigators with new methods which changed the ways in which diseases were understood and treated. Although there were many innovations in theoretical concepts of disease aetiology and empirical treatments, many were subsequently rejected for reasons of ineffectiveness or possible harm to the patient, sometimes after long periods of use. In its first part, the thesis draws upon publications from 1769 until 1950, mostly in the form of scientific articles and books. In the second part, the oral testimonies of health care professionals involved with the management and treatment of gastric and duodenal ulcers are added. The recorded testimonies of 28 witnesses have been preserved in written form as a supplement to this dissertation. The history of peptic ulcer disease over the past two hundred years as described in this thesis follows a broadly similar course to that of other diseases such as tuberculosis, syphilis and chronic renal disease which once dominated the lives of those who suffered from them and have largely become curable in recent years. This thesis is offered as an account of an equally fascinating and complex disease. ]]>

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Description Defense date not indicated; cited by UMI in 2014. Defense date not indicated; cited by UMI in 2014. Cited in ProQuest, UMI Dissertations Publishing. Proquest Document ID: 1557549125.


Citation URI
https://data.isiscb.org/isis/citation/CBB001567664/

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Authors & Contributors
Naumann, Kim
Howard Y. F. Choy
Lise Dumasy-Queffélec
Hélène Spengler
Radomski, Bartosz Michał
Ryan, William John
Concepts
Disease and diseases
Medicine
Medicine and culture
Health
Medicine and politics
Public health
Time Periods
19th century
20th century
18th century
17th century
21st century
Medieval
Places
United States
France
Great Britain
Africa
Guatemala
Rhodesia
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