Thesis ID: CBB001567338

Capturing Complexity: Experimental Systems and Epistemic Scaffolds in Animal Behavior Genetics (2011)


Nelson, Nicole Christine (Author)

Cornell University
Hilgartner, Stephen

Publication Date: 2011
Edition Details: Advisor: Hilgartner, Stephen.
Physical Details: 310 pp.
Language: English

This dissertation examines knowledge production practices in the field of animal behavior genetics. Drawing on ethnographic fieldwork at a laboratory at "Western University" that uses rodents to study the genetics of alcoholism and anxiety, I investigate how practitioners establish experimental systems to model human behavioral disorders in the laboratory and manage the excess of uncertainty that they associate with the "complexity" of behavior. To illuminate the dynamics of knowledge production in animal behavior genetics, I develop the metaphor of an "epistemic scaffold" to describe how practitioners establish and act on the conceptual foundations of particularmodels or tests.The image of a scaffold highlights two different processes taking place in the research community: the process of making specific links between the animal and the human using available data and theory, and the process of making more or less general claims about the utility of animal models and the applicability of animal behavior genetics findings. Methodological discussions about tests such as the elevated plus maze demonstrate how researchers negotiate about what counts as sound evidence for the connection of this test to human anxiety, and about whether researchers should claim that test models "anxiety" or only "anxiety-like behavior." The assumption that human behavioral disorders are likely to be "complex" animates many of these discussions about the practices and conceptual foundations of the field. I analyze how researchers stabilize particular representations of multi-faceted human behaviors such as binge drinking by developing new models, and show how some researchers use these models to highlight the role of environmental factors in behavior rather than solely "reducing" human behavior to genes. Different understandings of the "complexity" of human behavior are also associated with different expectations about the stability of animal behavior genetics experimental systems and how quickly knowledge will accumulate in the field. I demonstrate how practitioners attempt to manage expectations about what associations can be made between genes and behavior not only in the laboratory but also with other audiences in mind, such as funding agencies, policy makers, and the public.


Description Cited in Dissertation Abstracts International-A 73/07(E), Jan 2013. Proquest Document ID: 969168609.

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Authors & Contributors
Ramsden, Edmund
Kirk, Robert
Nelson, Nicole C.
Wilson, David A. H.
Patnode, Stephen R.
Gray, Liz
History of Science
Canadian Bulletin of Medical History/Bulletin Canadienne d'Histoire de la Medecine
VIET: Voprosy Istorii Estestvoznaniia i Tekhniki
History of the Human Sciences
Journal of the History of the Behavioral Sciences
Isis: International Review Devoted to the History of Science and Its Cultural Influences
University of Akron Press
University of Wisconsin at Madison
University of California, Santa Cruz
University of Chicago Press
Animal experimentation
Behavioral sciences
Animal behavior
Animal psychology
Pavlov, Ivan Petrovich
Calhoun, John B.
Keller, Fred Simmons
Miles, Walter Richard
Belyaev, Dmitry Vasilievich
Yerkes, Robert Mearns
Time Periods
20th century
19th century
20th century, early
20th century, late
21st century
United States
Great Britain
Alcoholics Anonymous (AA)
Primate Station, Sukhumi
National Institute of Mental Health (U.S.)

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