Social Arrangements in Genomic Science: How Microarray Data and Researchers Shaped Each Other (2011)
Rogers, Susan Nadia (Author)
Cambrosio, Alberto
McGill University (Canada)
Edition Details: Advisor: Cambrosio, Alberto
Physical Details: 238 pp.
Language: English
This thesis analyzes some of the social and organizational aspects involved in the production of microarray data through a case study of regulatory practices. It investigates a new blend of skills and expertise involved in biomedical regulation, and examines bottom-up standards initiatives in genomics from a sociology of science perspective. When the first published microarray experiment appeared in 1995, it carried with it a host of questions, opinions, visions, and disputes. With the development of further experiments, the comparability of results became an urgent issue to resolve. The massive datasets generated by each experiment were deemed too complex for single-handed assessment, leading to the involvement of public databases, curators, scientific journals, commercial investors, and other biomedical actors in the quest to stabilize the significance of microarray data. By 2001, the first of many standards initiatives was launched, orchestrating new connections of skills and tasks, and forming a socio-technical network of commitments that was intended to carry microarray data to the realm of scientific objectivity and widespread clinical usage. This thesis is based upon observational and interview data with microarray researchers, as well as primary scientific texts in the field of genomic science. Since widespread experimentation with microarray data began in the early 2000's, these data have led to a blending of professional cultures. My goal was to investigate how these new professional cultures coordinate and activate social networks, articulating them with regulation in order to turn a technological device into a fully 'working' scientific instrument, i.e. one that delivers consensually agreed upon scientific evidence. I argue that microarray technology was an early, unstable genomic technology that became largely sustained by new forms of concerted social action.
...MoreDescription Cited in ProQuest Diss. & Thes. . ProQuest Doc. ID 1037456566.
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