Article ID: CBB001552681

The Concept of the Causal Role of Chromosomes and Genes in Heredity and Development: Opponents from Darwin to Lysenko (2014)

unapi

The idea of chromosomes and genes as causal agents in development and heredity originated in late 19th-century cytology, and it was most strongly supported by Theodor Boveri and Edmund B. Wilson. The concept of genes, which was central and most fruitful in classical genetics, appeared, however, unappealing and insufficient to many for explaining complex biological phenomena such as development. Philosophical outlooks, among them “Lamarckian” and holistic predilections, played a significant role in scientists' objection to genes as causal factors. A wide conceptual gap between genetics and developmental biology ensued. The strongest attack on the concept of genes was launched by agronomist and politician Trofim Lysenko in the Soviet Union under Stalin. Brushing aside the “Mendelist-Morganist” methods of classical genetics, Lysenko put forward a holistic concept of heredity that incorporated development and heritable responses to environmental conditions, similar to Darwin's Pangenesis theory, though of course some 60 years later. Recent developments include the role of genes in research on epigenetic marks and in systems approaches based on embryological gene regulatory networks.

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Authors & Contributors
Volpone, Alessandro
Kolchinsky, Eduard I.
Wülfingen, Bettina Bock v.
Travis, Joseph
Schwartz, James Z.
Satzinger, Helga
Journals
History and Philosophy of the Life Sciences
Journal of the History of Biology
Science and Education
Physis: Rivista Internazionale di Storia della Scienza
Perspectives in Biology and Medicine
Osiris: A Research Journal Devoted to the History of Science and Its Cultural Influences
Publishers
Harvard University Press
Belknap Press of Harvard University Press
Cambridge University Press
Concepts
Genetics
Chromosomes
Evolution
Biology
Cytology
Lamarckism
People
Darwin, Charles Robert
Wilson, Edmund Beecher
Lysenko, Trofim Denisovich
Mendel, Gregor Johann
Darlington, Cyril Dean
Boveri, Theodor
Time Periods
20th century
19th century
20th century, early
20th century, late
18th century
Places
Soviet Union
Russia
Germany
France
Great Britain
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