Article
ID: CBB001510253

That 70s Show: Regulation, Evolution and Development beyond Molecular Genetics (2015)

unapi
Evolution Molecular biology Metabolism; physiological chemistry Experimental method Experimental biology DNA; RNA Genetic engineering 20th century, late Britten, Roy J. Davidson, Eric Zuckerkandl, Emile

This paper argues that the “long 1970s” (1969--1983) is an important though often overlooked period in the development of a rich landscape in the research of metabolism, development, and evolution. The period is marked by: shrinking public funding of basic science, shifting research agendas in molecular biology, the incorporation of new phenomena and experimental tools from previous biological research at the molecular level, and the development of recombinant DNA techniques. Research was reoriented towards eukaryotic cells and development, and in particular towards “giant” RNA processing and transcription. We will here focus on three different models of developmental regulation published in that period: the two models of eukaryotic genetic regulation at the transcriptional level that were developed by Georgii P. Georgiev on the one hand, and by Roy Britten and Eric Davidson on the other; and the model of genetic sufficiency and evolution of regulatory genes proposed by Emile Zuckerkandl. These three cases illustrate the range of exploratory hypotheses that characterised the challenging landscape of gene regulation in the 1970s, a period that in hindsight can be labelled as transitional, between the biology at the laboratory bench of the preceding period, and the biology of genetic engineering and intensive data-driven research that followed.

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Authors & Contributors
Fisher, Susie
Martynoga, Ben
Botelho, Alyssa
Yi, Doogab
Witkowski, Jan A.
Weber, Marcel
Journals
Journal of the History of Biology
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Social Studies of Science
Science as Culture
Physics World
Journal of Biosciences
Publishers
Troubador Publishing
Carnegie Mellon University
University of Minnesota Press
Rutgers University Press
Rutgers
Cold Spring Harbor Laboratory Press
Concepts
Molecular biology
DNA; RNA
Genetic engineering
Biotechnology
Science and law
Evolution
People
Anfinsen, Christian
Pauling, Linus Carl
Zuckerkandl, Emile
Temin, Howard M.
Kimura, Motoo
Fiers, Walter
Time Periods
20th century, late
21st century
Places
United States
Edinburgh
Belgium
Austria
Great Britain
Institutions
Science for the People (SftP)
Ghent University
Asilomar Conference on Recombinant DNA Molecules (1975)
Stanford University
Human Genome Project
Harvard University
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