Dhundi, Shraddha N. (Author)
Prajapati, P. K. (Author)
Makaradhvaja is a herbo-mineral Ras yana (rejuvenator) formulation containing gold which has been historically developed since 13th AD onwards. It is composed of processed gold, mercury and sulphur in different ratios (1:8:16; 1:8:24 or 1:8:48). Coined in 13th century, its pharmaceutical method of preparation went on changing up to 15th century. It is a well known, K pipakva preparation (drugs prepared in glass bottles using gradual heating) in the field of ayurvedic pharmaceutics. Makaradhvaja is a best example of combination of K pipakva and Kharal ya Ras yana (drugs prepared by trituration using mortar and pestle), as the sublimed product procured from the bottle neck is to be mixed with herbal drugs in a particular ratio by trituration. It is being administered with suitable vehicle in different diseased conditions for a period of one month to maximum three years.
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