Ankeny, Rachel A. (Author)
Leonelli, Sabina (Author)
Nelson, Nicole C. (Author)
Ramsden, Edmund (Author)
We examine the criteria used to validate the use of nonhuman organisms in North-American alcohol addiction research from the 1950s to the present day. We argue that this field, where the similarities between behaviors in humans and non-humans are particularly difficult to assess, has addressed questions of model validity by transforming the situatedness of non-human organisms into an experimental tool. We demonstrate that model validity does not hinge on the standardization of one type of organism in isolation, as often the case with genetic model organisms. Rather, organisms are viewed as necessarily situated: they cannot be understood as a model for human behavior in isolation from their environmental conditions. Hence the environment itself is standardized as part of the modeling process; and model validity is assessed with reference to the environmental conditions under which organisms are studied.
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Thesis
Nelson, Nicole Christine;
(2011)
Capturing Complexity: Experimental Systems and Epistemic Scaffolds in Animal Behavior Genetics
(/isis/citation/CBB001567338/)
Article
Angela N. H. Creager;
(2022)
Model Organisms Unbound
(/isis/citation/CBB532396920/)
Article
Karen A. Rader;
(2022)
Reflections on Making Mice (2004)
(/isis/citation/CBB321873815/)
Article
Kirk, Robert G. W.;
(2012)
“Standardization through Mechanization”: Germ-Free Life and the Engineering of the Ideal Laboratory Animal
(/isis/citation/CBB001230796/)
Article
Tarquin Holmes;
(2017)
The wild type as concept and in experimental practice: A history of its role in classical genetics and evolutionary theory
(/isis/citation/CBB016897194/)
Article
Kirk, Robert G. W.;
(2010)
A Brave New Animal for a Brave New World: The British Laboratory Animals Bureau and the Constitution of International Standards of Laboratory Animal Production and Use, circa 1947--1968
(/isis/citation/CBB000954051/)
Book
Georg Striedter;
(2022)
Model Systems in Biology: History, Philosophy, and Practical Concerns
(/isis/citation/CBB401616956/)
Thesis
Metlay, Grischa Jeremy;
(2010)
Learning from Drunk Monkeys: Expert Approaches to Alcohol and Drug Problems in Modern America
(/isis/citation/CBB001567222/)
Article
Pemberton, Neil;
(2013)
The Bloodhound's Nose Knows? Dogs and Detection in Anglo-American Culture
(/isis/citation/CBB001213635/)
Article
Goodwin, C. James;
(2014)
Walter Miles and His Research on Low Dose Alcohol (1914--1924): Shifting The Emphasis from Intoxication to Impairment
(/isis/citation/CBB001550681/)
Book
Waltraud Ernst;
Thomas Muller;
(2022)
Alcohol, Psychiatry and Society: Comparative and Transnational Perspectives, C. 1700–1990s
(/isis/citation/CBB907976441/)
Thesis
Erica O'Neil;
(2016)
Fetal Risk, Federal Response: How Fetal Alcohol Syndrome Influenced the Adoption of Alcohol Health Warning Labels
(/isis/citation/CBB757766325/)
Article
Leonelli, Sabina;
(2007)
Growing Weed, Producing Knowledge: An Epistemic History of Arabidopsis thaliana
(/isis/citation/CBB000931558/)
Article
Brad Bolman;
(2021)
Pig Mentations: Race and Face in Radiobiology
(/isis/citation/CBB398870305/)
Chapter
Ramsden, Edmund;
(2011)
Travelling Facts about Crowded Rats: Rodent Experimentation and the Human Sciences
(/isis/citation/CBB001000231/)
Article
Wilson, David A. H.;
(2002)
Experimental Animal Behaviour Studies: The Loss of Initiative in Britain 100 Years Ago
(/isis/citation/CBB000202701/)
Thesis
Russell, Mark C.;
(2002)
Heredity and the Human Condition: A Study of 20th-Century Genetic Accounts of Alcoholism
(/isis/citation/CBB001561852/)
Chapter
Markel, Arkady L.;
Trut, Lyudmila N.;
(2011)
Behavior, Stress, and Evolution in Light of the Novosibirsk Selection Experiments
(/isis/citation/CBB001500095/)
Book
Rheinberger, Hans-Jörg;
(2010)
An Epistemology of the Concrete
(/isis/citation/CBB001023158/)
Book
Stephanie Elizabeth Mohr;
(2018)
First in Fly: Drosophila Research and Biological Discovery
(/isis/citation/CBB668155327/)
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