Article ID: CBB001320605

Malaria and Quinine Resistance: A Medical and Scientific Issue between Brazil and Germany (1907--19) (2014)

unapi

This article addresses the discussion about quinine-resistant malaria plasmodium in the early decades of the twentieth century. Observed by Arthur Neiva in Rio de Janeiro in 1907, the biological and social resistance of malaria sufferers to preventive and curative treatment with quinine was corroborated three years later by Oswaldo Cruz during the construction of the Madeira-Mamoré Railway in the Brazilian Amazon. Likewise in 1910, ailing German workers were transferred from Brazil to Hamburg's Institute for Maritime and Tropical Diseases, where quinine resistance was confirmed by Bernard Nocht and Heinrich Werner. When the First World War saw failures in treating and preventing malaria with quinine along with violent outbreaks of the disease on the Turkish and Balkan fronts, resistance to this alkaloid became the topic of the day within the field of experimental medicine in Germany. New attempts were made to account for the resistance, especially by the physician Ernst Rodenwaldt, who explored the topic by applying modern theories on heredity. The present article offers a preliminary survey and analysis of pronouncements about quinine resistance, shedding new light on the circulation of knowledge in the field of tropical medicine. Keywords : Malaria, Quinine Resistance, History of Tropical Medicine, Arthur Neiva, Ernest Rodenwaldt

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Authors & Contributors
Silva, André Felipe Cândido da
Pieters, Toine
Hoogte, Arjo Roersch van der
Costa, Renato da Gama-Rosa
Sanglard, Gisele
Paulini, Ernest
Journals
História, Ciências, Saúde---Manguinhos
Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
Journal of Medical Biography
Gesnerus
Journal of the History of Medicine and Allied Sciences
Publishers
Duke University Press
University of California, San Diego
Concepts
Tropical medicine
Malaria
Public health
Medicine
Colonialism
Physicians; doctors
People
Cruz, Oswaldo Gonçalves
Porto d'Ave, A.
Mello-Leitão, Cândido de
Afonso Henriques de Lima Barreto
Koch, Robert
Rocha Lima, Henrique de
Places
Brazil
Rio de Janeiro (Brazil)
Germany
Philippines
Amazon River Region (South America)
France
Times
20th century, early
20th century
19th century
Institutions
Rockefeller Foundation
Fundação Oswaldo Cruz (Brazil)
Hamburg Tropical Institute
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