Craig, G. Wayne (Author)
Kauffman, George B. (Author)
The Chemical Educator
Volume: 11, no. 6
Issue: 6
Pages: 427-436
Albert Hofmann's early curiosity about nature's wonders led him to the field of chemistry. He began his career by identifying the structure of the natural polysaccharide, chitin, and the cardiac-active Scilla glycosides. But it was his synthesis of LSD, an analogue of the ergot alkaloids, that led to a revolution in the pharmaceutical industry, inspiring researchers to understand how the structure of a molecule is recognized and how this recognition triggers a physiological response, as well as a revolution in the social identity crisis of America and Europe during the 1960s. The incredible potency of this drug challenged the conventional lock-and-key model that Emil Fischer had proposed for enzymes. In fact, the astounding physiological properties of LSD and its abuse may have overshadowed the scientific expertise and outstanding qualities of its discoverer, Albert Hofmann, who celebrated his 100th birthday this year in good health. The first article in this series (pp 413-420) sketches Hofmann's discovery of LSD; its use as an adjunct to meditation, creativity, and consciousness expansion; treatment of the mentally ill; and its abuse as a pleasure drug. The second article discusses LSD as a catalyst in the pharmaceutical revolution (pp 421-426). We have also reviewed the Festschrift commemorating his 100th birthday (pp 451-452)
...MoreSimilar Citations
Article
Craig, G. Wayne;
Kauffman, George B.;
(2006)
LSD: Catalyst for a Pharmacological Revolution
(/isis/citation/CBB001252559/)
Article
Kauffman, George B.;
Mayo, Isaac;
Craig, G. Wayne;
(2006)
LSD: Albert Hofmann's “Problem Child”
(/isis/citation/CBB001252558/)
Article
Jeffrey I. Seeman;
(2023)
The Back Story: Gilbert Stork and the Sweetness of Quinine
(/isis/citation/CBB592773188/)
Article
Büttner, Johannes;
(2004)
“Auf diese Entdeckung lege ich einigen Werth und ärgere mich, daß sie mir entrißen worden ist”: Friedrich Wöhler und die Hippursäure
(/isis/citation/CBB000500807/)
Article
Behrman, E. J.;
Guido Panzarasa;
(2016)
Comment and Response: Rediscovering Pyrotartaric Acid
(/isis/citation/CBB552364127/)
Article
Jehane Ragai;
(2018)
Snapshots of chemical practices in Ancient Egypt
(/isis/citation/CBB168722705/)
Article
Trimble, Virginia;
(2010)
The Origins and Abundances of the Chemical Elements before 1957: From Prout's Hypothesis to Pasadena
(/isis/citation/CBB001020942/)
Article
Seth C. Ramussen;
(2016)
On the Origin of “Synthetic Metals”: Herbert McCoy, Alfred Ubbelohde, and the Development of Metals from Nonmetallic Elements
(/isis/citation/CBB830177070/)
Article
M. Paolieri;
(2017)
Ferdinand Münz: EDTA and 40 years of inventions
(/isis/citation/CBB966298641/)
Article
Tontini, Andrea;
(2004)
On the Limits of Chemical Knowledge
(/isis/citation/CBB000600062/)
Article
Witty, Michael;
(2012)
The Process for 2,3,5-Triphenyltetrazolium Chloride Synthesis, an Intellectual Property Seized Immediately after World War I
(/isis/citation/CBB001252047/)
Article
Teichmann, Herbert;
(2004)
175 Jahre Wöhlers Harnstoff-Synthese
(/isis/citation/CBB000500806/)
Article
Miyamoto, Masaki;
(2007)
A History of Japanese Methanol Production Technology: The Navy Research Institute Method
(/isis/citation/CBB000831467/)
Article
Seth C. Rasmussen;
(2017)
Cuprene: A Historical Curiosity Along the Path to Polyacetylene
(/isis/citation/CBB478566118/)
Article
Laura Colli;
Antonio Guarna;
(2018)
The dextrorotatory sweet asparagine of Arnaldo Piutti: the original product is conserved in Florence
(/isis/citation/CBB447570859/)
Article
Zhang, Li;
(2003)
Peter P. T. Sah and the Synthesis of Vitamin C in China and Europe
(/isis/citation/CBB000410987/)
Article
Bensaude-Vincent, Bernadette;
(2009)
Biomimetic Chemistry and Synthetic Biology: A Two-way Traffic across the Borders
(/isis/citation/CBB001021317/)
Article
Kauffman, George B.;
(2004)
John C. Bailar, Jr. (1904--1991): Father of American Coordination Chemistry---A Centennial Retrospect
(/isis/citation/CBB001252539/)
Article
Kauffman, George B.;
(2004)
Sir William Ramsay: Noble Gas Pioneer---On the 100th Anniversary of His Nobel Prize
(/isis/citation/CBB001252541/)
Article
Kauffman, George B.;
Chooljian, Steven H.;
(2001)
Friedrich Wöhler (1800--1882), on the Bicentennial of His Birth
(/isis/citation/CBB001252527/)
Be the first to comment!